Pub. Date : 2003 Jul
PMID : 12819770
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | In contrast to the related granzyme B (GzmB), GzmA forms a stable disulfide-linked homodimer and triggers target-cell death in a caspase-independent way. | Disulfides | granzyme A | Homo sapiens |
2 | Limited proteolysis of a high-molecular-mass complex containing SET (also named putative HLA-associated protein II or PHAPII), PHAPI (pp32, leucine-rich acidic nuclear protein) and HMG2 by GzmA liberates NM23-H1, a Mg2+-dependent DNase that causes single-stranded breaks in nuclear DNA. | magnesium ion | granzyme A | Homo sapiens |