Title : Crystal structure of the apoptosis-inducing human granzyme A dimer.

Pub. Date : 2003 Jul

PMID : 12819770






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 In contrast to the related granzyme B (GzmB), GzmA forms a stable disulfide-linked homodimer and triggers target-cell death in a caspase-independent way. Disulfides granzyme A Homo sapiens
2 Limited proteolysis of a high-molecular-mass complex containing SET (also named putative HLA-associated protein II or PHAPII), PHAPI (pp32, leucine-rich acidic nuclear protein) and HMG2 by GzmA liberates NM23-H1, a Mg2+-dependent DNase that causes single-stranded breaks in nuclear DNA. magnesium ion granzyme A Homo sapiens