Pub. Date : 2009 Aug 6
PMID : 19506301
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we show that GzmA cleaves the DNA damage sensor poly(adenosine 5"-diphosphate-ribose) polymerase-1 (PARP-1) after Lys(498) in its automodification domain, separating the DNA binding domain from the catalytic domain, which interferes with repair of GzmA-induced DNA damage and enhances susceptibility to GzmA-mediated death. | Lysine | granzyme A | Homo sapiens |
| 2 | In this study, we show that GzmA cleaves the DNA damage sensor poly(adenosine 5"-diphosphate-ribose) polymerase-1 (PARP-1) after Lys(498) in its automodification domain, separating the DNA binding domain from the catalytic domain, which interferes with repair of GzmA-induced DNA damage and enhances susceptibility to GzmA-mediated death. | Lysine | granzyme A | Homo sapiens |
| 3 | In this study, we show that GzmA cleaves the DNA damage sensor poly(adenosine 5"-diphosphate-ribose) polymerase-1 (PARP-1) after Lys(498) in its automodification domain, separating the DNA binding domain from the catalytic domain, which interferes with repair of GzmA-induced DNA damage and enhances susceptibility to GzmA-mediated death. | Lysine | granzyme A | Homo sapiens |