Title : 1,25(OH)2D3 increases cytotoxicity and exocytosis in lymphokine-activated killer cells.

Pub. Date : 1993 Oct

PMID : 8276128






4 Functional Relationships(s)
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1 This effect was dose-dependent, detectable already at 10(-11) M attaining 44 +/- 7% increase at 10(-8) M. 1,25-dihydroxyvitamin D3 increased LAK cell content of the cytotoxic granule granzyme A by 21%. Calcitriol granzyme A Homo sapiens
2 Secretion of granzyme A by LAK cells was triggered by 12-O-tetradecanoylphorbol 13-acetate and the calcium ionophore A23187. Tetradecanoylphorbol Acetate granzyme A Homo sapiens
3 Secretion of granzyme A by LAK cells was triggered by 12-O-tetradecanoylphorbol 13-acetate and the calcium ionophore A23187. Calcimycin granzyme A Homo sapiens
4 1,25-dihydroxyvitamin D3 decreased the lag preceding secretion, increased the rate constant of exocytosis and the fraction of granzyme A cell content secreted. Calcitriol granzyme A Homo sapiens