Title : Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis.

Pub. Date : 2005 Mar

PMID : 15780992






4 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 GzmA induces a rapid increase in reactive oxygen species and mitochondrial transmembrane potential loss, but does not cleave bid or cause apoptogenic factor release. Reactive Oxygen Species granzyme A Homo sapiens
2 SET complex nuclear translocation, which occurs within minutes of peroxide or GzmA treatment, is dependent on superoxide generation since superoxide scavengers block it. Superoxides granzyme A Homo sapiens
3 SET complex nuclear translocation, which occurs within minutes of peroxide or GzmA treatment, is dependent on superoxide generation since superoxide scavengers block it. Superoxides granzyme A Homo sapiens
4 Superoxide scavengers also block apoptosis by CTLs expressing GzmA and/or GzmB. Superoxides granzyme A Homo sapiens