Title : TGFβR1 Blockade with Galunisertib (LY2157299) Enhances Anti-Neuroblastoma Activity of the Anti-GD2 Antibody Dinutuximab (ch14.18) with Natural Killer Cells.

Pub. Date : 2017 Feb 1

PMID : 27756784






1 Functional Relationships(s)
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Protein Name
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1 In NK cells treated in vitro with exogenous TGFbeta1, galunisertib suppressed SMAD2 phosphorylation and restored the expression of DNAM-1, NKp30, and NKG2D cytotoxicity receptors and the TRAIL death ligand, the release of perforin and granzyme A, and the direct cytotoxicity and ADCC of aNK cells against neuroblastoma cells. LY-2157299 granzyme A Homo sapiens