Pub. Date : 2016 Oct
PMID : 27439606
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Histone H4 is cleaved by granzyme A during staurosporine-induced cell death in B-lymphoid Raji cells. | Staurosporine | granzyme A | Homo sapiens |
| 2 | Here, we demonstrated that histone H4 was cleaved by GzmA during staurosporine-induced cell death; however, in the presence of caspase inhibitors, staurosporine-treated Raji cells underwent necroptosis instead of apoptosis. | Staurosporine | granzyme A | Homo sapiens |
| 3 | Here, we demonstrated that histone H4 was cleaved by GzmA during staurosporine-induced cell death; however, in the presence of caspase inhibitors, staurosporine-treated Raji cells underwent necroptosis instead of apoptosis. | Staurosporine | granzyme A | Homo sapiens |
| 4 | Furthermore, histone H4 cleavage was blocked by the GzmA inhibitor nafamostat mesylate and by GzmA knockdown using siRNA. | nafamostat | granzyme A | Homo sapiens |
| 5 | These results suggest that histone H4 is a novel substrate for GzmA in staurosporine-induced cells. | Staurosporine | granzyme A | Homo sapiens |