Tetradecanoylphorbol Acetate

AKT serine/threonine kinase 1 ; Homo sapiens







60 Article(s)
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1 33034831 Expression of Akt1 and p-Akt1 in peripheral T cell subsets of multiple sclerosis patients. 2021 Dec 3
2 33890137 Megakaryoblastic leukemia: a study on novel role of clinically significant long non-coding RNA signatures in megakaryocyte development during treatment with phorbol ester. 2021 Dec 1
3 34119884 Urinary exosomes-based Engineered Nanovectors for Homologously Targeted Chemo-Chemodynamic Prostate Cancer Therapy via abrogating EGFR/AKT/NF-kB/IkB signaling. 2021 Aug 1
4 31939617 Inhibition of TPA‑induced metastatic potential by morin hydrate in MCF‑7 human breast cancer cells via the Akt/GSK‑3β/c‑Fos signaling pathway. 2020 Feb 2
5 33023539 NFAT2 overexpression suppresses the malignancy of hepatocellular carcinoma through inducing Egr2 expression. 2020 Oct 6 1
6 30590137 Suppression of PMA-induced human fibrosarcoma HT-1080 invasion and metastasis by kahweol via inhibiting Akt/JNK1/2/p38 MAPK signal pathway and NF-κB dependent transcriptional activities. 2019 Mar 2
7 30707387 Umbilical Cord Blood Mesenchymal Stem Cells Enhance Lipopolysaccharide-Induced IL-10 and IL-37 Production in THP-1 Cells. 2019 Jun 2
8 31026389 Praeruptorin-B Inhibits 12-O-Tetradecanoylphorbol-13-Acetate-Induced Cell Invasion by Targeting AKT/NF-κB via Matrix Metalloproteinase-2/-9 Expression in Human Cervical Cancer Cells. 2019 2
9 31343893 Boiled Abalone Byproduct Peptide Exhibits Anti-Tumor Activity in HT1080 Cells and HUVECs by Suppressing the Metastasis and Angiogenesis in Vitro. 2019 Aug 14 2
10 29601810 2',3-dihydroxy-5-methoxybiphenyl suppresses fMLP-induced superoxide anion production and cathepsin G release by targeting the β-subunit of G-protein in human neutrophils. 2018 Jun 15 2
11 27393705 Dual Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like Disease in Mice. 2017 Jan 10 1
12 28073348 Wild carrot pentane-based fractions suppress proliferation of human HaCaT keratinocytes and protect against chemically-induced skin cancer. 2017 Jan 10 1
13 29123208 Differential T Cell Signaling Pathway Activation by Tacrolimus and Belatacept after Kidney Transplantation: Post Hoc Analysis of a Randomised-Controlled Trial. 2017 Nov 9 1
14 25787879 Dehydroglyasperin C suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K. 2016 May 1
15 27035791 Gold-conjugated resveratrol nanoparticles attenuate the invasion and MMP-9 and COX-2 expression in breast cancer cells. 2016 Jun 1
16 25301262 Dihydroartemisinin suppresses glioma proliferation and invasion via inhibition of the ADAM17 pathway. 2015 Mar 1
17 25866363 Naringenin suppresses TPA-induced tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells. 2015 Jun 25 1
18 26485540 Evaluation of novel Akt1 inhibitors as anticancer agents using virtual co-crystallized pharmacophore generation. 2015 Nov 1
19 24433534 Genistein inhibits tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells. 2014 Jan 16 1
20 25143809 The Heterochromatin-1 Phosphorylation Contributes to TPA-Induced AP-1 Expression. 2014 Jul 1
21 25520561 A Role for the Cavin-3/Matrix Metalloproteinase-9 Signaling Axis in the Regulation of PMA-Activated Human HT1080 Fibrosarcoma Cell Neoplastic Phenotype. 2014 1
22 23151889 Surfactin suppresses TPA-induced breast cancer cell invasion through the inhibition of MMP-9 expression. 2013 Jan 1
23 23288142 Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells. 2013 May 1
24 23615401 Induction of heme oxygenase-1 and inhibition of TPA-induced matrix metalloproteinase-9 expression by andrographolide in MCF-7 human breast cancer cells. 2013 Aug 2
25 22151918 Cucurbitacin B inhibits 12-O-tetradecanoylphorbol 13-acetate-induced invasion and migration of human hepatoma cells through inactivating mitogen-activated protein kinase and PI3K/Akt signal transduction pathways. 2012 Apr 2
26 22382313 Kalopanaxsaponin A inhibits the invasion of human oral squamous cell carcinoma by reducing metalloproteinase-9 mRNA stability and protein trafficking. 2012 1
27 22465218 Selective inhibition of MMP-9 gene expression by mangiferin in PMA-stimulated human astroglioma cells: involvement of PI3K/Akt and MAPK signaling pathways. 2012 Jul 1
28 22505246 Phosphoinositol 3-kinase, a novel target molecule for the inhibitory effects of juglone on TPA-induced cell transformation. 2012 Jul 1
29 22740037 Aromatic-turmerone attenuates invasion and expression of MMP-9 and COX-2 through inhibition of NF-κB activation in TPA-induced breast cancer cells. 2012 Dec 2
30 21205932 Insulin signaling in retinal neurons is regulated within cholesterol-enriched membrane microdomains. 2011 Mar 1
31 21705328 Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively. 2011 Aug 26 2
32 20550117 Anti-invasive effect of a rare mushroom, Ganoderma colossum , on human hepatoma cells. 2010 Jul 14 1
33 20554189 12-O-Tetradecanoyl phorbol-13-acetate (TPA)-induced growth arrest is increased by silibinin by the down-regulation of cyclin B1 and cdc2 and the up-regulation of p21 expression in MDA-MB231 human breast cancer cells. 2010 Dec 1 1
34 20826143 Phorbol 12-myristate 13-acetate inhibits the antilipolytic action of insulin, probably via the activity of protein kinase Cε. 2010 Dec 1 2
35 21124749 Pharmacological targeting of β-adrenergic receptor functions abrogates NF-κB signaling and MMP-9 secretion in medulloblastoma cells. 2010 Nov 15 1
36 19288401 Effect of seven tricyclic diterpenoids from needles of Taxus media var. Hicksii on stimulus-induced superoxide generation, tyrosyl or serine/threonine phosphorylation and translocation of cytosolic compounds to the cell membrane in human neutrophils. 2009 Jun 1
37 19420016 Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells. 2009 Jul 4
38 19447859 Pterostilbene inhibited tumor invasion via suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells. 2009 Jul 1
39 18483250 Reduced susceptibility to two-stage skin carcinogenesis in mice with low circulating insulin-like growth factor I levels. 2008 May 15 1
40 18713840 Akt phosphorylates the TR3 orphan receptor and blocks its targeting to the mitochondria. 2008 Nov 1
41 18941896 Proteasome-dependent inactivation of Akt is essential for 12-O-tetradecanoylphorbol 13-acetate-induced apoptosis in vascular smooth muscle cells. 2008 Dec 6
42 17699780 The role of glycogen synthase kinase 3beta in the transformation of epidermal cells. 2007 Aug 15 1
43 17803520 Involvement of protein kinase C in melatonin's oncostatic effect in C6 glioma cells. 2007 Oct 1
44 16455999 Involvement of protein kinase Cepsilon in the negative regulation of Akt activation stimulated by granulocyte colony-stimulating factor. 2006 Feb 15 3
45 16846837 Taurine chloramine inhibits PMA-stimulated superoxide production in human neutrophils perhaps by inhibiting phosphorylation and translocation of p47(phox). 2006 Sep 2
46 16940331 Regulation of Akt/PKB by phosphatidylinositol 3-kinase-dependent and -independent pathways in B-cell chronic lymphocytic leukemia cells: role of protein kinase C{beta}. 2006 Dec 2
47 16044407 Inhibition of TPA-induced cyclooxygenase-2 (COX-2) expression by apigenin through downregulation of Akt signal transduction in human keratinocytes. 2005 Oct 7
48 15252145 Activation of protein kinase C betaII/epsilon-c-Jun NH2-terminal kinase pathway and inhibition of mitogen-activated protein/extracellular signal-regulated kinase 1/2 phosphorylation in antitumor invasive activity induced by the polymethoxy flavonoid, nobiletin. 2004 Jul 1
49 15489897 PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways. 2004 Dec 2 1
50 12388064 Elevated L-PGDS activity contributes to PMA-induced apoptosis concomitant with downregulation of PI3-K. 2003 Jan 1