Title : Evaluation of novel Akt1 inhibitors as anticancer agents using virtual co-crystallized pharmacophore generation.

Pub. Date : 2015 Nov

PMID : 26485540






1 Functional Relationships(s)
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1 To confirm the inhibition of Akt1 phosphorylation, MCF10A cell line was co-treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) and 100 muM of each of the most potent 13 Akt inhibitors (1-13). Tetradecanoylphorbol Acetate AKT serine/threonine kinase 1 Homo sapiens