Title : Elevated L-PGDS activity contributes to PMA-induced apoptosis concomitant with downregulation of PI3-K.

Pub. Date : 2003 Jan

PMID : 12388064






1 Functional Relationships(s)
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1 Treatment of cells with PMA or L-PGDS decreased phosphatidylinositol 3-kinase (PI3-K) activity and concomitantly inhibited protein kinase B (PKB/Akt) phosphorylation, which led to the hypophosphorylation and activation of Bad. Tetradecanoylphorbol Acetate AKT serine/threonine kinase 1 Homo sapiens