PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18941896-0 2008 Proteasome-dependent inactivation of Akt is essential for 12-O-tetradecanoylphorbol 13-acetate-induced apoptosis in vascular smooth muscle cells. Tetradecanoylphorbol Acetate 58-94 AKT serine/threonine kinase 1 Homo sapiens 37-40 18941896-3 2008 We found that TPA treatment induced SMC apoptosis through the rapid downregulation of Akt phosphorylation. Tetradecanoylphorbol Acetate 14-17 AKT serine/threonine kinase 1 Homo sapiens 86-89 18941896-4 2008 The inhibition of Akt activation by TPA was markedly reduced by inhibitors of protein phosphatase 2A and proteasome. Tetradecanoylphorbol Acetate 36-39 AKT serine/threonine kinase 1 Homo sapiens 18-21 18941896-5 2008 Moreover, TPA promoted the ubiquitination of p-Akt, whereas inhibition of TPA-induced PKC activation suppressed the downregulation and ubiquitination of p-Akt. Tetradecanoylphorbol Acetate 10-13 AKT serine/threonine kinase 1 Homo sapiens 47-50 18941896-5 2008 Moreover, TPA promoted the ubiquitination of p-Akt, whereas inhibition of TPA-induced PKC activation suppressed the downregulation and ubiquitination of p-Akt. Tetradecanoylphorbol Acetate 74-77 AKT serine/threonine kinase 1 Homo sapiens 155-158 18941896-6 2008 Taken together, these results demonstrate that TPA triggers inactivation of Akt, at least in part, through PKC and Ubiquitin-proteasome degradation, thereby contributing to SMC apoptosis. Tetradecanoylphorbol Acetate 47-50 AKT serine/threonine kinase 1 Homo sapiens 76-79 18713840-8 2008 Consistently, insulin was also found to induce the phosphorylation of TR3 and abolish 12-O-tetradecanoylphorbol-13-acetate-induced mitochondrial localization, which was dependent upon the activation of the phophatidylinositol-3-OH-kinase-Akt signaling pathway. Tetradecanoylphorbol Acetate 86-122 AKT serine/threonine kinase 1 Homo sapiens 238-241 17803520-6 2007 Activation of PKC by incubation with triphorbol ester acetate (TPA) blocks the inhibitory effect of melatonin on Akt and NF-kappaB activity. Tetradecanoylphorbol Acetate 63-66 AKT serine/threonine kinase 1 Homo sapiens 113-116 18483250-7 2008 In addition, reduced activation of both Akt and the mammalian target of rapamycin (mTOR) was observed in LID mice following TPA treatment relative to wild-type controls. Tetradecanoylphorbol Acetate 124-127 AKT serine/threonine kinase 1 Homo sapiens 40-43 17699780-9 2007 EGF and TPA-stimulated Ser9 phosphorylation was mediated by phosphoinositide-3-kinase (PI3K)/Akt and protein kinase C (PKC) pathways. Tetradecanoylphorbol Acetate 8-11 AKT serine/threonine kinase 1 Homo sapiens 93-96 16940331-6 2006 PMA induced the phosphorylation of Akt at Ser-473 and Thr-308 and the phosphorylation of Akt substrates, independently of PI-3K in B-CLL cells. Tetradecanoylphorbol Acetate 0-3 AKT serine/threonine kinase 1 Homo sapiens 35-38 16940331-6 2006 PMA induced the phosphorylation of Akt at Ser-473 and Thr-308 and the phosphorylation of Akt substrates, independently of PI-3K in B-CLL cells. Tetradecanoylphorbol Acetate 0-3 AKT serine/threonine kinase 1 Homo sapiens 89-92 16455999-3 2006 PMA treatment also rapidly attenuated sustained Akt activation mediated by a carboxy truncated G-CSF receptor, expressed in patients with acute myeloid leukemia evolving from severe congenital neutropenia. Tetradecanoylphorbol Acetate 0-3 AKT serine/threonine kinase 1 Homo sapiens 48-51 16846837-6 2006 Translocation of p47(phox), p67(phox) and Rac was increased in response to PMA, and Tau-Cl inhibited the PMA-stimulated translocation of p47(phox) and p67(phox) to plasma membrane without affecting the translocation of Rac. Tetradecanoylphorbol Acetate 75-78 AKT serine/threonine kinase 1 Homo sapiens 28-45 16846837-6 2006 Translocation of p47(phox), p67(phox) and Rac was increased in response to PMA, and Tau-Cl inhibited the PMA-stimulated translocation of p47(phox) and p67(phox) to plasma membrane without affecting the translocation of Rac. Tetradecanoylphorbol Acetate 75-78 AKT serine/threonine kinase 1 Homo sapiens 42-45 16455999-4 2006 The inhibitory effect of PMA was abolished by pretreatment of cells with specific PKC inhibitor GF109203X, suggesting that the PKC pathway negatively regulates Akt activation. Tetradecanoylphorbol Acetate 25-28 AKT serine/threonine kinase 1 Homo sapiens 160-163 16455999-5 2006 Ro31-8820, a PKCepsilon inhibitor, also abrogated PMA-mediated inhibition of Akt activation, whereas rottlerin and Go6976, inhibitors of PKCdelta and PKCalphabetaI, respectively, exhibited no significant effects. Tetradecanoylphorbol Acetate 50-53 AKT serine/threonine kinase 1 Homo sapiens 77-80 12401518-4 2003 In contrast to the Akt stimulation caused by PKC inhibitors, PMA attenuated Akt/PKB phosphorylation. Tetradecanoylphorbol Acetate 61-64 AKT serine/threonine kinase 1 Homo sapiens 76-79 16044407-6 2005 The induction of COX-2 elicited by TPA correlated with increased activation of Akt kinase and cell treatment with the PI3 kinase inhibitor, LY294002, blocked TPA induction of COX-2. Tetradecanoylphorbol Acetate 158-161 AKT serine/threonine kinase 1 Homo sapiens 79-82 16044407-7 2005 In cells treated with TPA and apigenin, the inhibition of COX-2 expression correlated with inhibition of Akt kinase activation. Tetradecanoylphorbol Acetate 22-25 AKT serine/threonine kinase 1 Homo sapiens 105-108 16044407-8 2005 Apigenin-mediated inhibition of TPA-induced COX-2 expression was reversed by transient transfection with constitutively active Akt (CA-Akt). Tetradecanoylphorbol Acetate 32-35 AKT serine/threonine kinase 1 Homo sapiens 127-130 16044407-8 2005 Apigenin-mediated inhibition of TPA-induced COX-2 expression was reversed by transient transfection with constitutively active Akt (CA-Akt). Tetradecanoylphorbol Acetate 32-35 AKT serine/threonine kinase 1 Homo sapiens 135-138 16044407-11 2005 These data show that apigenin inhibits TPA-mediated COX-2 expression by blocking signal transduction of Akt and that apigenin also blocks AA release, which may contribute to its chemopreventive activity. Tetradecanoylphorbol Acetate 39-42 AKT serine/threonine kinase 1 Homo sapiens 104-107 15489897-2 2004 In this report, we show that PMA-stimulated activation of PKC-eta in U-251 GBM cells resulted in activation of both Akt and the mammalian target of rapamycin (mTOR) signaling pathways and an increase in cell proliferation. Tetradecanoylphorbol Acetate 29-32 AKT serine/threonine kinase 1 Homo sapiens 116-119 15252145-7 2004 However, nobiletin was found to augment the phosphorylation of c-Jun NH2-terminal kinase (JNK), a downstream signal factor of the PI3K-Akt pathway, in TPA-treated HT-1080 cells. Tetradecanoylphorbol Acetate 151-154 AKT serine/threonine kinase 1 Homo sapiens 135-138 12594296-7 2003 In eosinophils stimulated with PMA, a pronounced shift of cytosolic Rac to p22(phox)-positive plasma membrane was observed by confocal microscopy, whereas neutrophils directed Rac2 mainly to intracellular sites coexpressing p22(phox). Tetradecanoylphorbol Acetate 31-34 AKT serine/threonine kinase 1 Homo sapiens 68-71 12388064-4 2003 Treatment of cells with PMA or L-PGDS decreased phosphatidylinositol 3-kinase (PI3-K) activity and concomitantly inhibited protein kinase B (PKB/Akt) phosphorylation, which led to the hypophosphorylation and activation of Bad. Tetradecanoylphorbol Acetate 24-27 AKT serine/threonine kinase 1 Homo sapiens 141-148 16044407-0 2005 Inhibition of TPA-induced cyclooxygenase-2 (COX-2) expression by apigenin through downregulation of Akt signal transduction in human keratinocytes. Tetradecanoylphorbol Acetate 14-17 AKT serine/threonine kinase 1 Homo sapiens 100-103 16044407-6 2005 The induction of COX-2 elicited by TPA correlated with increased activation of Akt kinase and cell treatment with the PI3 kinase inhibitor, LY294002, blocked TPA induction of COX-2. Tetradecanoylphorbol Acetate 35-38 AKT serine/threonine kinase 1 Homo sapiens 79-82 12801607-7 2003 Furthermore, stimulation of PKC, using short-term 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment, markedly inhibited the stimulatory effects of EGF on Akt phosphorylation. Tetradecanoylphorbol Acetate 50-86 AKT serine/threonine kinase 1 Homo sapiens 157-160 12801607-7 2003 Furthermore, stimulation of PKC, using short-term 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment, markedly inhibited the stimulatory effects of EGF on Akt phosphorylation. Tetradecanoylphorbol Acetate 88-91 AKT serine/threonine kinase 1 Homo sapiens 157-160 12734380-4 2003 Inhibition of Akt activity in human neutrophils by an inhibitory peptide significantly attenuated fMLP-stimulated, but not PMA-stimulated, superoxide release. Tetradecanoylphorbol Acetate 123-126 AKT serine/threonine kinase 1 Homo sapiens 14-17 12401518-4 2003 In contrast to the Akt stimulation caused by PKC inhibitors, PMA attenuated Akt/PKB phosphorylation. Tetradecanoylphorbol Acetate 61-64 AKT serine/threonine kinase 1 Homo sapiens 80-83 33023539-5 2020 The expression of Egr2 and FasL, and the phosphorylation of AKT and ERK, after ionomycin and PMA co-stimulation, was detected, while the Ca2+ mobilization stimulated by K+ solution was determined. Tetradecanoylphorbol Acetate 93-96 AKT serine/threonine kinase 1 Homo sapiens 60-63 12048182-5 2002 Phorbol 12-myristate 13-acetate, a differentiation-inducing stimulus, potently activates the Ras-Raf-MEK-ERK pathway but only weakly activates PI3K/Akt and does not trigger the cross-talk. Tetradecanoylphorbol Acetate 0-31 AKT serine/threonine kinase 1 Homo sapiens 148-151 12400610-6 2002 Evidence that RAFTK is a modulator of Akt came from phorbol myristic acetate (PMA) stimulation. Tetradecanoylphorbol Acetate 78-81 AKT serine/threonine kinase 1 Homo sapiens 38-41 11929788-9 2002 In addition, Akt, a downstream effector of PI3-kinase activity, was phosphorylated by TPA and IL-4 in B-CLL cells, though PI3-kinase had no effect on PKC-dependent phosphorylation of Akt. Tetradecanoylphorbol Acetate 86-89 AKT serine/threonine kinase 1 Homo sapiens 13-16 33890137-10 2021 Importantly, this study reveals the activation of ERK1/2 and PI3K/AKT pathway in PMA-induced Dami cell differentiation into MK. Tetradecanoylphorbol Acetate 81-84 AKT serine/threonine kinase 1 Homo sapiens 66-69 12377207-5 2002 VEGF-induced Akt activation was prevented by down-regulation of PKC induced by prolonged pretreatment with the phorbol ester, PMA. Tetradecanoylphorbol Acetate 126-129 AKT serine/threonine kinase 1 Homo sapiens 13-16 8805224-6 1996 Activation of the serum response element by v-Abl was inhibited by Rac N17 and Ras N17, whereas activation of the TPA response element was inhibited by Rac N17 but not by Ras N17. Tetradecanoylphorbol Acetate 114-117 AKT serine/threonine kinase 1 Homo sapiens 152-155 8407934-6 1993 After activation of neutrophils with phorbol 12-myristate 13-acetate or formyl-methionyl-leucyl-phenylalanine, Rac was translocated from the cytosol to the plasma membrane, and this translocation corresponded temporally with the translocation of p47-phox and p67-phox and with the generation of superoxide. Tetradecanoylphorbol Acetate 37-68 AKT serine/threonine kinase 1 Homo sapiens 111-114 33034831-6 2021 After stimulation with phorbol myristate acetate/ionomycin, the Akt1 and phosphorylated-Akt1 (p-Akt1) levels of T cell subsets were detected with intracellular staining using flow cytometry. Tetradecanoylphorbol Acetate 23-48 AKT serine/threonine kinase 1 Homo sapiens 64-68 33034831-6 2021 After stimulation with phorbol myristate acetate/ionomycin, the Akt1 and phosphorylated-Akt1 (p-Akt1) levels of T cell subsets were detected with intracellular staining using flow cytometry. Tetradecanoylphorbol Acetate 23-48 AKT serine/threonine kinase 1 Homo sapiens 88-92 33034831-6 2021 After stimulation with phorbol myristate acetate/ionomycin, the Akt1 and phosphorylated-Akt1 (p-Akt1) levels of T cell subsets were detected with intracellular staining using flow cytometry. Tetradecanoylphorbol Acetate 23-48 AKT serine/threonine kinase 1 Homo sapiens 88-92 34119884-7 2021 In addition, the blockage of bypassing EGFR/AKT/NF-kB/IkB signaling pathway is greatly enhanced via elevated intracellular PMA/Fe-HSA@DOX nanoparticles (NPs). Tetradecanoylphorbol Acetate 123-126 AKT serine/threonine kinase 1 Homo sapiens 44-47 31939617-8 2020 Taken together, these results demonstrated that morin hydrate reduced the metastatic potential in TPA-treated MCF-7 human breast cancer cells via the inhibition of MMPs, uPA and uPAR, and the underlying Akt/GSK-3beta/c-Fos pathway. Tetradecanoylphorbol Acetate 98-101 AKT serine/threonine kinase 1 Homo sapiens 203-206 31343893-6 2019 BABP inhibits phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase (MMP) expression and activity by blocking mitogen-activated protein kinases (MAPKs) and NF-kappaB signaling and hypoxia-induced vascular endothelial growth factor (VEGF) secretion and hypoxia inducible factor (HIF)-1alpha accumulation through suppressing the AKT/mTOR signal pathway. Tetradecanoylphorbol Acetate 14-45 AKT serine/threonine kinase 1 Homo sapiens 344-347 31939617-0 2020 Inhibition of TPA-induced metastatic potential by morin hydrate in MCF-7 human breast cancer cells via the Akt/GSK-3beta/c-Fos signaling pathway. Tetradecanoylphorbol Acetate 14-17 AKT serine/threonine kinase 1 Homo sapiens 107-110 31343893-6 2019 BABP inhibits phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase (MMP) expression and activity by blocking mitogen-activated protein kinases (MAPKs) and NF-kappaB signaling and hypoxia-induced vascular endothelial growth factor (VEGF) secretion and hypoxia inducible factor (HIF)-1alpha accumulation through suppressing the AKT/mTOR signal pathway. Tetradecanoylphorbol Acetate 47-50 AKT serine/threonine kinase 1 Homo sapiens 344-347 25787879-6 2016 TPA-induced phosphorylation of p38, JNK1/2 and Akt was also suppressed by DGC. Tetradecanoylphorbol Acetate 0-3 AKT serine/threonine kinase 1 Homo sapiens 47-50 27393705-7 2017 Del treatment of interleukin-22 or TPA-stimulated normal human epidermal keratinocytes (NHEKs) significantly inhibited proliferation, activation of PI3K/Akt/mTOR components, and secretion of proinflammatory cytokines and chemokines. Tetradecanoylphorbol Acetate 35-38 AKT serine/threonine kinase 1 Homo sapiens 153-156 28073348-15 2017 CONCLUSION: The present data reveal that F2 fraction has a remarkable antitumor activity against DMBA/TPA-induced skin carcinogenesis, an effect that may be mediated through inhibition of the MAPK/ERK and PI3K/AKT pathways. Tetradecanoylphorbol Acetate 102-105 AKT serine/threonine kinase 1 Homo sapiens 210-213 27035791-12 2016 Our findings revealed that the anti-invasive effects of Rev-AuNPs in response to TPA-stimulation were mediated by the suppression of MMP-9, COX-2, NF-kappaB, AP-1, PI3K/Akt and ERK and/or the activation of HO-1 signaling cascades. Tetradecanoylphorbol Acetate 81-84 AKT serine/threonine kinase 1 Homo sapiens 169-172 30707387-3 2019 After co-culture of UCB-MSCs and phorbol 12-myristate 13-acetate (PMA)-activated human THP-1 cells using a transwell system, it showed that LPS significantly induced increases in the expression levels of interleukin 10 (IL-10), interleukin 37 (IL-37), phospho-PI3K (p-PI3K), and phospho-Akt (p-Akt) in macrophages. Tetradecanoylphorbol Acetate 66-69 AKT serine/threonine kinase 1 Homo sapiens 287-290 30707387-3 2019 After co-culture of UCB-MSCs and phorbol 12-myristate 13-acetate (PMA)-activated human THP-1 cells using a transwell system, it showed that LPS significantly induced increases in the expression levels of interleukin 10 (IL-10), interleukin 37 (IL-37), phospho-PI3K (p-PI3K), and phospho-Akt (p-Akt) in macrophages. Tetradecanoylphorbol Acetate 66-69 AKT serine/threonine kinase 1 Homo sapiens 294-297 30590137-0 2019 Suppression of PMA-induced human fibrosarcoma HT-1080 invasion and metastasis by kahweol via inhibiting Akt/JNK1/2/p38 MAPK signal pathway and NF-kappaB dependent transcriptional activities. Tetradecanoylphorbol Acetate 15-18 AKT serine/threonine kinase 1 Homo sapiens 104-107 30590137-8 2019 KA repressed the PMA-induced phosphorylation of Akt, c-Jun N-terminal kinase (JNK) 1/2, and p38 MAPK, which are signaling molecules upstream of MMP-9 expression. Tetradecanoylphorbol Acetate 17-20 AKT serine/threonine kinase 1 Homo sapiens 48-51 31026389-0 2019 Praeruptorin-B Inhibits 12-O-Tetradecanoylphorbol-13-Acetate-Induced Cell Invasion by Targeting AKT/NF-kappaB via Matrix Metalloproteinase-2/-9 Expression in Human Cervical Cancer Cells. Tetradecanoylphorbol Acetate 24-60 AKT serine/threonine kinase 1 Homo sapiens 96-99 31026389-12 2019 CONCLUSION: These results suggested that Pra-B-mediated inhibition of TPA-induced cell metastasis involved the suppression of p-AKT/NF-kappaB via MMP-2/-9 expression in HeLa cells. Tetradecanoylphorbol Acetate 70-73 AKT serine/threonine kinase 1 Homo sapiens 128-131 29601810-10 2018 On the contrary, phorbol 12-myristate 13-acetate (PMA)-induced phosphorylation of Src, AKT, P38, PKC and membrane localization of p47ph x and P40ph x remained unaffected. Tetradecanoylphorbol Acetate 17-48 AKT serine/threonine kinase 1 Homo sapiens 87-90 29601810-10 2018 On the contrary, phorbol 12-myristate 13-acetate (PMA)-induced phosphorylation of Src, AKT, P38, PKC and membrane localization of p47ph x and P40ph x remained unaffected. Tetradecanoylphorbol Acetate 50-53 AKT serine/threonine kinase 1 Homo sapiens 87-90 29123208-5 2017 After activation with PMA/ionomycin, p-p38MAPK and p-AKT were significantly inhibited in CD4+ and CD8+ T cells when TAC was given, compared to pre-transplantation. Tetradecanoylphorbol Acetate 22-25 AKT serine/threonine kinase 1 Homo sapiens 53-56 25520561-8 2014 Furthermore, recombinant cavin-3 significantly prevented PMA-mediated dephosphorylation of AKT, a crucial regulator in MMP-9 transcription. Tetradecanoylphorbol Acetate 57-60 AKT serine/threonine kinase 1 Homo sapiens 91-94 26485540-7 2015 To confirm the inhibition of Akt1 phosphorylation, MCF10A cell line was co-treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) and 100 muM of each of the most potent 13 Akt inhibitors (1-13). Tetradecanoylphorbol Acetate 126-129 AKT serine/threonine kinase 1 Homo sapiens 29-33 25866363-6 2015 Additionally, it suppressed TPA-induced activation of ERK/phosphatidylinositol 3-kinase/Akt upstream of NF-kappaB and AP-1. Tetradecanoylphorbol Acetate 28-31 AKT serine/threonine kinase 1 Homo sapiens 88-91 25301262-6 2015 EGFR and AKT phosphorylation was enhanced by stimulation with the ADAM17 agonist chemokine phorbol myristate acetate. Tetradecanoylphorbol Acetate 91-116 AKT serine/threonine kinase 1 Homo sapiens 9-12 25143809-5 2014 We show that TPA-induced Akt1 directly phosphorylates HP1gamma, abrogates its suppressive function and increases the interaction between histone H3 and 14-3-3epsilon. Tetradecanoylphorbol Acetate 13-16 AKT serine/threonine kinase 1 Homo sapiens 25-29 24433534-7 2014 Moreover, Gen suppressed TPA-induced activation of ERK/phosphatidylinositol 3-kinase/Akt upstream of NF-kappaB and AP-1. Tetradecanoylphorbol Acetate 25-28 AKT serine/threonine kinase 1 Homo sapiens 85-88 22740037-9 2012 Thus, transfection of breast cancer cells with PI3K/Akt and ERK1/2 siRNAs significantly decreased TPA-induced MMP-9 and COX-2 expression. Tetradecanoylphorbol Acetate 98-101 AKT serine/threonine kinase 1 Homo sapiens 52-55 23615401-9 2013 Furthermore, TPA-induced extracellular signal-regulated kinase (ERK) 1/2 and Akt phosphorylation and the DNA binding activity of activator protein-1 (AP-1) and nuclear factor-kappa B (NF-kappaB) were attenuated by pretreatment with AP and HO-1 end products. Tetradecanoylphorbol Acetate 13-16 AKT serine/threonine kinase 1 Homo sapiens 77-80 23615401-10 2013 In conclusion, these results suggest that AP inhibits TPA-induced cell migration and invasion by reducing MMP-9 activation, which is mediated mainly by inhibition of the ERK1/2 and phosphatidylinositol 3-kinase/Akt signaling pathways and subsequent AP-1 and NF-kappaB transactivation. Tetradecanoylphorbol Acetate 54-57 AKT serine/threonine kinase 1 Homo sapiens 211-214 23288142-6 2013 TPA-induced activation of ERK1, Akt, and PKCdelta was attenuated by DHA, whereas LA attenuated only ERK1 activation. Tetradecanoylphorbol Acetate 0-3 AKT serine/threonine kinase 1 Homo sapiens 32-35 23151889-6 2013 Furthermore, surfactin strongly repressed the TPA-induced phosphorylation of Akt and extracellular signal-regulated kinase (ERK). Tetradecanoylphorbol Acetate 46-49 AKT serine/threonine kinase 1 Homo sapiens 89-92 22740037-10 2012 These results suggest that ar-turmerone suppressed the TPA-induced up-regulation of MMP-9 and COX-2 expression by blocking NF-kappaB, PI3K/Akt, and ERK1/2 signaling in human breast cancer cells. Tetradecanoylphorbol Acetate 55-58 AKT serine/threonine kinase 1 Homo sapiens 139-142 22465218-8 2012 Further mechanistic studies demonstrated that mangiferin inhibits the binding of NF-kappaB and AP-1 to the MMP-9 promoter and suppresses the PMA-induced phosphorylation of Akt and MAP kinases, which are upstream signaling molecules in MMP-9 expression. Tetradecanoylphorbol Acetate 141-144 AKT serine/threonine kinase 1 Homo sapiens 172-175 22505246-5 2012 Juglone significantly suppressed TPA-induced protein kinase B (AKT) and c-Jun phosphorylation and c-fos activation, but not mitogen-activated protein-kinase kinase (MEK), extracellular signaling-regulated kinase (ERK) or 90 kDa ribosomal protein S6 kinase (RSK) phosphorylation. Tetradecanoylphorbol Acetate 33-36 AKT serine/threonine kinase 1 Homo sapiens 63-66 21205932-10 2011 We also demonstrated that insulin localizes phosphorylated Akt to lipid microdomains and that PMA reduces phosphorylated Akt. Tetradecanoylphorbol Acetate 94-97 AKT serine/threonine kinase 1 Homo sapiens 121-124 22382313-6 2012 KPS-A treatment suppressed PMA-induced phosphorylation of extracellular signal regulated kinase (ERK)1/2 and Akt. Tetradecanoylphorbol Acetate 27-30 AKT serine/threonine kinase 1 Homo sapiens 109-112 21705328-0 2011 Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively. Tetradecanoylphorbol Acetate 43-79 AKT serine/threonine kinase 1 Homo sapiens 240-243 21705328-0 2011 Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively. Tetradecanoylphorbol Acetate 81-84 AKT serine/threonine kinase 1 Homo sapiens 240-243 22151918-0 2012 Cucurbitacin B inhibits 12-O-tetradecanoylphorbol 13-acetate-induced invasion and migration of human hepatoma cells through inactivating mitogen-activated protein kinase and PI3K/Akt signal transduction pathways. Tetradecanoylphorbol Acetate 24-60 AKT serine/threonine kinase 1 Homo sapiens 179-182 22151918-7 2012 RESULTS: Cucurbitacin B has significantly suppressed 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced cell invasion and migration in a concentration-dependent manner, which was accompanied with suppression of TPA-induced MMP-9 expression through inactivation of phosphorylation of extracellular signal-regulated kinase (ERK) 1/2, p38 and Akt. Tetradecanoylphorbol Acetate 93-96 AKT serine/threonine kinase 1 Homo sapiens 342-345 19420016-5 2009 Using specific inhibitors, we confirmed that PMA-induced cell invasion and MMP-9 expression is primarily regulated by nuclear factor-kappa B (NF-kappaB) activation via phosphatidylinositol 3-kinase (PI3K)/Akt and activator protein-1 (AP-1) activation via extracellular signal-regulated kinase (ERK)1/2. Tetradecanoylphorbol Acetate 45-48 AKT serine/threonine kinase 1 Homo sapiens 205-208 20826143-6 2010 Inhibitors of phosphatidylinositol 3-kinase (PI3-K), Akt, and phosphodiesterase 3B (PDE3B) diminished the PMA effect. Tetradecanoylphorbol Acetate 106-109 AKT serine/threonine kinase 1 Homo sapiens 53-56 20826143-7 2010 PMA inhibited insulin-stimulated phosphorylation of Tyr in insulin receptor beta subunit and Ser/Thr in Akt. Tetradecanoylphorbol Acetate 0-3 AKT serine/threonine kinase 1 Homo sapiens 104-107 20550117-7 2010 The EEGC also showed an inhibitory effect on the PMA-induced phosphorylation of extracellular signal-regulated kinase (ERK1/2) and protein kinase B (Akt) in cytosol, as well as the activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) levels in the nucleus of HepG2 cells. Tetradecanoylphorbol Acetate 49-52 AKT serine/threonine kinase 1 Homo sapiens 149-152 19420016-0 2009 Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells. Tetradecanoylphorbol Acetate 28-31 AKT serine/threonine kinase 1 Homo sapiens 97-100 20554189-12 2010 Therefore, we have demonstrated that silibinin has an additive effect on TPA-induced growth arrest through the PI-3-kinase/Akt-dependent pathway. Tetradecanoylphorbol Acetate 73-76 AKT serine/threonine kinase 1 Homo sapiens 123-126 21124749-9 2010 Although propranolol, at up to 100 muM, did not affect cell viability, it potentiated PMA- mediated signaling that ultimately led to diminished phosphorylation of Akt. Tetradecanoylphorbol Acetate 86-89 AKT serine/threonine kinase 1 Homo sapiens 163-166 19420016-6 2009 KPS-A decreased PMA-induced transcriptional activation of NF-kappaB and AP-1 and inhibited PMA-induced phosphorylation of ERK1/2 and Akt. Tetradecanoylphorbol Acetate 91-94 AKT serine/threonine kinase 1 Homo sapiens 133-136 19447859-7 2009 Moreover, pterostilbene can suppress TPA-induced activation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase, c-Jun N-terminal kinases 1/2 and phosphatidylinositol 3-kinase/Akt and protein kinase C that are upstream of NF-kappaB and AP-1. Tetradecanoylphorbol Acetate 37-40 AKT serine/threonine kinase 1 Homo sapiens 207-210 19420016-9 2009 These results suggest that KPS-A inhibits PMA-induced invasion by reducing MMP-9 activation, mainly via the PI3K/Akt/NF-kappaB and PKCdelta/ERK/AP-1 pathways in MCF-7 cells and blocks tumor growth and MMP-9-mediated invasiveness in mice with breast carcinoma. Tetradecanoylphorbol Acetate 42-45 AKT serine/threonine kinase 1 Homo sapiens 113-116 19288401-8 2009 The compounds also suppressed fMLP- and AA-induced tyrosyl or PMA-induced serine/threonine phosphorylation, and translocation of cytosolic compounds, p47 (phox), p67 (phox) and Rac to the cell membrane in parallel with the suppression of the stimulus-induced superoxide generation. Tetradecanoylphorbol Acetate 62-65 AKT serine/threonine kinase 1 Homo sapiens 177-180