Title : Selective inhibition of MMP-9 gene expression by mangiferin in PMA-stimulated human astroglioma cells: involvement of PI3K/Akt and MAPK signaling pathways.

Pub. Date : 2012 Jul

PMID : 22465218






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Further mechanistic studies demonstrated that mangiferin inhibits the binding of NF-kappaB and AP-1 to the MMP-9 promoter and suppresses the PMA-induced phosphorylation of Akt and MAP kinases, which are upstream signaling molecules in MMP-9 expression. Tetradecanoylphorbol Acetate AKT serine/threonine kinase 1 Homo sapiens