Pub. Date : 2006 Feb 15
PMID : 16455999
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PMA treatment also rapidly attenuated sustained Akt activation mediated by a carboxy truncated G-CSF receptor, expressed in patients with acute myeloid leukemia evolving from severe congenital neutropenia. | Tetradecanoylphorbol Acetate | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | The inhibitory effect of PMA was abolished by pretreatment of cells with specific PKC inhibitor GF109203X, suggesting that the PKC pathway negatively regulates Akt activation. | Tetradecanoylphorbol Acetate | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Ro31-8820, a PKCepsilon inhibitor, also abrogated PMA-mediated inhibition of Akt activation, whereas rottlerin and Go6976, inhibitors of PKCdelta and PKCalphabetaI, respectively, exhibited no significant effects. | Tetradecanoylphorbol Acetate | AKT serine/threonine kinase 1 | Homo sapiens |