Title : Induction of heme oxygenase-1 and inhibition of TPA-induced matrix metalloproteinase-9 expression by andrographolide in MCF-7 human breast cancer cells.

Pub. Date : 2013 Aug

PMID : 23615401






2 Functional Relationships(s)
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1 Furthermore, TPA-induced extracellular signal-regulated kinase (ERK) 1/2 and Akt phosphorylation and the DNA binding activity of activator protein-1 (AP-1) and nuclear factor-kappa B (NF-kappaB) were attenuated by pretreatment with AP and HO-1 end products. Tetradecanoylphorbol Acetate AKT serine/threonine kinase 1 Homo sapiens
2 In conclusion, these results suggest that AP inhibits TPA-induced cell migration and invasion by reducing MMP-9 activation, which is mediated mainly by inhibition of the ERK1/2 and phosphatidylinositol 3-kinase/Akt signaling pathways and subsequent AP-1 and NF-kappaB transactivation. Tetradecanoylphorbol Acetate AKT serine/threonine kinase 1 Homo sapiens