Pub. Date : 2012 Apr
PMID : 22151918
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Cucurbitacin B inhibits 12-O-tetradecanoylphorbol 13-acetate-induced invasion and migration of human hepatoma cells through inactivating mitogen-activated protein kinase and PI3K/Akt signal transduction pathways. | Tetradecanoylphorbol Acetate | AKT serine/threonine kinase 1 | Homo sapiens |
2 | RESULTS: Cucurbitacin B has significantly suppressed 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced cell invasion and migration in a concentration-dependent manner, which was accompanied with suppression of TPA-induced MMP-9 expression through inactivation of phosphorylation of extracellular signal-regulated kinase (ERK) 1/2, p38 and Akt. | Tetradecanoylphorbol Acetate | AKT serine/threonine kinase 1 | Homo sapiens |