Guanosine Triphosphate

AKT serine/threonine kinase 1 ; Homo sapiens







191 Article(s)
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1 35186026 Cdc42/Rac Interactive Binding Containing Effector Proteins in Unicellular Protozoans With Reference to Human Host: Locks of the Rho Signaling. 2022 1
2 33502586 VIP modulates human macrophages phenotype via FPRL1 via activation of RhoA-GTPase and PLC pathways. 2021 Mar 1
3 34607932 Efficacy of Rac and Cdc42 Inhibitor MBQ-167 in Triple-negative Breast Cancer. 2021 Dec 1
4 32159236 Requirement of GTP binding for TIF-90-regulated ribosomal RNA synthesis and oncogenic activities in human colon cancer cells. 2020 Oct 2
5 32411442 Reduced Circulating Endothelial Progenitor Cells and Downregulated GTCPH I Pathway Related to Endothelial Dysfunction in Premenopausal Women with Isolated Impaired Glucose Tolerance. 2020 2
6 33238110 Hetero-oligomerization of Rho and Ras GTPases Connects GPCR Activation to mTORC2-AKT Signaling. 2020 Nov 24 2
7 31172470 Soluble Regulatory Proteins for Activation of NOX Family NADPH Oxidases. 2019 1
8 29743547 The Protease Activated Receptor2 Promotes Rab5a Mediated Generation of Pro-metastatic Microvesicles. 2018 May 9 1
9 29858187 Targeting Rac and Cdc42 GTPases in Cancer. 2018 Jun 15 1
10 30560466 Anti-Invasive and Anti-Proliferative Effects of shRNA-Loaded Poly(Lactide-Co-Glycolide) Nanoparticles Following RAN Silencing in MDA-MB231 Breast Cancer Cells. 2018 Dec 17 1
11 28386321 Acid fibroblast growth factor preserves blood-brain barrier integrity by activating the PI3K-Akt-Rac1 pathway and inhibiting RhoA following traumatic brain injury. 2017 1
12 28601080 MicroRNA-630 Suppresses Epithelial-to-Mesenchymal Transition by Regulating FoxM1 in Gastric Cancer Cells. 2017 Jun 1
13 28666462 Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis. 2017 Jun 30 1
14 29114068 Receptor tyrosine kinase activation of RhoA is mediated by AKT phosphorylation of DLC1. 2017 Dec 4 3
15 27588399 Loss of Par3 promotes lung adenocarcinoma metastasis through 14-3-3ΞΆ protein. 2016 Sep 27 1
16 25676701 An Osteoclastic Transmembrane Protein-Tyrosine Phosphatase Enhances Osteoclast Activity in Part by Dephosphorylating EphA4 in Osteoclasts. 2015 Aug 1
17 26425463 Pleiotropic effects of statins. 2015 Sep-Oct 1
18 24269559 Mechanistic target of rapamycin (mTOR) signaling genes in decapod crustaceans: cloning and tissue expression of mTOR, Akt, Rheb, and p70 S6 kinase in the green crab, Carcinus maenas, and blackback land crab, Gecarcinus lateralis. 2014 Feb 1
19 24316235 RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells. 2014 Mar 2
20 24321316 Role of Rac GTPase activating proteins in regulation of NADPH oxidase in human neutrophils. 2014 Mar 1
21 24526684 ADP ribosylation factor 6 (Arf6) acts through FilGAP protein to down-regulate Rac protein and regulates plasma membrane blebbing. 2014 Apr 4 1
22 24598074 Role of the Rho GTPase Rac in the activation of the phagocyte NADPH oxidase: outsourcing a key task. 2014 2
23 25056956 Arachidonic acid induces direct interaction of the p67(phox)-Rac complex with the phagocyte oxidase Nox2, leading to superoxide production. 2014 Sep 5 2
24 23263278 Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion. 2013 Feb 1
25 23326220 Computational analysis of Rho GTPase cycling. 2013 1
26 23518456 In silico tissue-distribution of human Rho family GTPase activating proteins. 2013 Apr-Jun 1
27 23657011 Reciprocal regulation of PKA and Rac signaling. 2013 May 21 5
28 23936510 Evidence for a novel mechanism of the PAK1 interaction with the Rho-GTPases Cdc42 and Rac. 2013 1
29 24322054 Interplay of PKA and Rac: fine-tuning of Rac localization and signaling. 2013 Oct-Dec 2
30 22144279 FRET-based imaging of Rac and Cdc42 activation during Fc-receptor-mediated phagocytosis in macrophages. 2012 1
31 22404134 p21-Activated kinase inhibitors: a patent review. 2012 Mar 1
32 22448228 The adaptor molecule Nck localizes the WAVE complex to promote actin polymerization during CEACAM3-mediated phagocytosis of bacteria. 2012 1
33 22520755 Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. 2012 Apr 20 1
34 23033535 Rho GEFs and cancer: linking gene expression and metastatic dissemination. 2012 Oct 2 1
35 23050005 Dimerization of DOCK2 is essential for DOCK2-mediated Rac activation and lymphocyte migration. 2012 1
36 23285096 Green tea polyphenols induce p53-dependent and p53-independent apoptosis in prostate cancer cells through two distinct mechanisms. 2012 2
37 21787760 Understanding SOS (Son of Sevenless). 2011 Nov 1 1
38 22027834 Role of scaffold protein afadin dilute domain-interacting protein (ADIP) in platelet-derived growth factor-induced cell movement by activating Rac protein through Vav2 protein. 2011 Dec 16 2
39 20007513 GTPase-Rac enhances depolarization-induced superoxide production by the macula densa during tubuloglomerular feedback. 2010 Feb 1
40 20127720 Control of intestinal promoter activity of the cellular migratory regulator gene ELMO3 by CDX2 and SP1. 2010 Apr 15 1
41 20231290 Pertussis toxin up-regulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation. 2010 May 14 1
42 20592186 alpha2beta1 integrin controls association of Rac with the membrane and triggers quiescence of endothelial cells. 2010 Jul 15 1
43 18802007 SWAP-70 regulates RhoA/RhoB-dependent MHCII surface localization in dendritic cells. 2009 Feb 12 1
44 19176382 GGAP2/PIKE-a directly activates both the Akt and nuclear factor-kappaB pathways and promotes prostate cancer progression. 2009 Feb 1 2
45 19451552 CCL21 mediates CD4+ T-cell costimulation via a DOCK2/Rac-dependent pathway. 2009 Jul 16 1
46 18480413 Phospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane. 2008 Jul 6
47 18495429 The cAMP-activated GTP exchange factor, Epac1 upregulates plasma membrane and nuclear Akt kinase activities in 8-CPT-2-O-Me-cAMP-stimulated macrophages: Gene silencing of the cAMP-activated GTP exchange Epac1 prevents 8-CPT-2-O-Me-cAMP activation of Akt activity in macrophages. 2008 Aug 2
48 18505730 Dissociation of Rac1(GDP).RhoGDI complexes by the cooperative action of anionic liposomes containing phosphatidylinositol 3,4,5-trisphosphate, Rac guanine nucleotide exchange factor, and GTP. 2008 Aug 8 2
49 18513786 S1P induced changes in epithelial ovarian cancer proteolysis, invasion, and attachment are mediated by Gi and Rac. 2008 Aug 1
50 19074886 Phospholipase Cgamma1 is required for metastasis development and progression. 2008 Dec 15 1