Title : Requirement of GTP binding for TIF-90-regulated ribosomal RNA synthesis and oncogenic activities in human colon cancer cells.

Pub. Date : 2020 Oct

PMID : 32159236






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Overexpression of activated AKT induces TIF-90 T310, but not a GTP-binding site (TIF-90 T310N) mutant, to translocate into the nucleolus and increase rRNA synthesis. Guanosine Triphosphate AKT serine/threonine kinase 1 Homo sapiens
2 Complementing this result, treatment with mycophenolic acid (MPA), an inhibitor of GTP production, dissociates TIF-90 from Pol I and hence abolishes AKT-increased rRNA synthesis by way of TIF-90 activation. Guanosine Triphosphate AKT serine/threonine kinase 1 Homo sapiens