Pub. Date : 2013 May 21
PMID : 23657011
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The formation of this transient core complex depends on binary interactions with PKA subunits, cAMP levels and cellular GTP-loading accounting for bidirectional consequences on PKA and Rac downstream signaling. | Guanosine Triphosphate | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | We show that GTP-Rac stabilizes the inactive PKA holoenzyme. | Guanosine Triphosphate | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | However, beta-adrenergic receptor-mediated activation of GTP-Rac-bound PKA routes signals to the Raf-Mek-Erk cascade, which is critically implicated in cell proliferation. | Guanosine Triphosphate | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | We describe a further mechanism of how cAMP enhances nuclear Erk1/2 signaling: It emanates from transphosphorylation of p21-activated kinases in their evolutionary conserved kinase-activation loop through GTP-Rac compartmentalized PKA activities. | Guanosine Triphosphate | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | Our findings offer additional mechanistic insights how beta-adrenergic receptor-controlled PKA activities enhance GTP-Rac-mediated activation of nuclear Erk1/2 signaling. | Guanosine Triphosphate | AKT serine/threonine kinase 1 | Homo sapiens |