Title : Interplay of PKA and Rac: fine-tuning of Rac localization and signaling.

Pub. Date : 2013 Oct-Dec

PMID : 24322054






2 Functional Relationships(s)
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1 We demonstrated that GTP-activated Rac acts as a dual kinase-tuning scaffold for p21-activated kinase (PAK) and PKA activities. Guanosine Triphosphate AKT serine/threonine kinase 1 Homo sapiens
2 We showed that receptor-triggered PKA trans-phosphorylation of GTP-Rac-organized PAK contributes to elevations of nuclear Erk1/2 signaling and proliferation. Guanosine Triphosphate AKT serine/threonine kinase 1 Homo sapiens