| 1 |
34801402 | Cholesterol metabolism is decreased in patients with diminished ovarian reserve. | 2022 Jan |
1 |
| 2 |
34939274 | Squalene synthase predicts poor prognosis in stage I-III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression. | 2022 Mar |
2 |
| 3 |
35093030 | Raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by FDFT1: a review. | 2022 Jan 29 |
2 |
| 4 |
35552960 | SQLE inhibition suppresses the development of pancreatic ductal adenocarcinoma and enhances its sensitivity to chemotherapeutic agents in vitro. | 2022 May 12 |
1 |
| 5 |
32602556 | Impairing committed cholesterol biosynthesis in white matter astrocytes, but not grey matter astrocytes, enhances in vitro myelination. | 2021 Mar |
3 |
| 6 |
33991130 | Bisphosphonate inhibitors of squalene synthase protect cells against cholesterol-dependent cytolysins. | 2021 Jun |
2 |
| 7 |
34377370 | Genome-scale integration of transcriptome and metabolome unveils squalene synthase and dihydrofolate reductase as targets against AML cells resistant to chemotherapy. | 2021 |
1 |
| 8 |
34440098 | Enzymes in the Cholesterol Synthesis Pathway: Interactomics in the Cancer Context. | 2021 Jul 26 |
1 |
| 9 |
34444698 | Orphan Nuclear Receptor RORγ Modulates the Genome-Wide Binding of the Cholesterol Metabolic Genes during Mycotoxin-Induced Liver Injury. | 2021 Jul 25 |
1 |
| 10 |
34680069 | Mevalonate Kinase Deficiency and Squalene Synthase Inhibitor (TAK-475): The Balance to Extinguish the Inflammation. | 2021 Sep 30 |
2 |
| 11 |
34726809 | Osteoblasts impair cholesterol synthesis in chondrocytes via Notch1 signalling. | 2021 Dec |
1 |
| 12 |
32557793 | New applications of squalene synthase inhibitors: Membrane cholesterol as a therapeutic target. | 2020 Sep |
5 |
| 13 |
32626771 | Bioinformatical Analysis of miRNA-mRNA Interaction Network Underlying Macrophage Aging and Cholesterol-Responsive Difference between Young and Aged Macrophages. | 2020 |
3 |
| 14 |
32699268 | Post-transcriptional air pollution oxidation to the cholesterol biosynthesis pathway promotes pulmonary stress phenotypes. | 2020 Jul 22 |
1 |
| 15 |
32827918 | Bavachinin inhibits cholesterol synthesis enzyme FDFT1 expression via AKT/mTOR/SREBP-2 pathway. | 2020 Nov |
4 |
| 16 |
32845096 | Understanding the Functional Impact of VOC-Ozone Mixtures on the Chemistry of RNA in Epithelial Lung Cells. | 2020 Jul |
5 |
| 17 |
32862200 | Squalene synthase promotes the invasion of lung cancer cells via the osteopontin/ERK pathway. | 2020 Aug 29 |
5 |
| 18 |
30578317 | The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis. | 2019 Jan 16 |
1 |
| 19 |
30774923 | Oxidative steps during the biosynthesis of squalestatin S1. | 2019 Jan 28 |
1 |
| 20 |
29159775 | Toxic effects of phytol and retinol on human glioblastoma cells are associated with modulation of cholesterol and fatty acid biosynthetic pathways. | 2018 Feb |
1 |
| 21 |
29355536 | A mathematical model of the mevalonate cholesterol biosynthesis pathway. | 2018 Apr 14 |
1 |
| 22 |
29710800 | Discovery of Potential Inhibitors of Squalene Synthase from Traditional Chinese Medicine Based on Virtual Screening and In Vitro Evaluation of Lipid-Lowering Effect. | 2018 Apr 28 |
1 |
| 23 |
29732977 | Rational Discovery of Novel Squalene Synthase Inhibitors through Pharmacophore Modelling. | 2018 |
1 |
| 24 |
29909962 | Squalene Synthase Deficiency: Clinical, Biochemical, and Molecular Characterization of a Defect in Cholesterol Biosynthesis. | 2018 Jul 5 |
3 |
| 25 |
26922723 | Discovering Peptide Inhibitors of Human Squalene Synthase Through Screening the Phage-Displayed Cyclic Peptide c7c Library. | 2016 Jun |
1 |
| 26 |
24582769 | Atorvastatin inhibits CXCR7 induction to reduce macrophage migration. | 2014 May 1 |
1 |
| 27 |
25152164 | Squalene synthase induces tumor necrosis factor receptor 1 enrichment in lipid rafts to promote lung cancer metastasis. | 2014 Sep 15 |
1 |
| 28 |
22234961 | Aryl hydrocarbon receptor regulates the cholesterol biosynthetic pathway in a dioxin response element-independent manner. | 2012 Jun |
1 |
| 29 |
22398368 | 5-Aza-2'-deoxycytidine induced growth inhibition of leukemia cells through modulating endogenous cholesterol biosynthesis. | 2012 Jul |
1 |
| 30 |
22579571 | Oligomeric amyloid-β peptide affects the expression of genes involved in steroid and lipid metabolism in primary neurons. | 2012 Aug |
1 |
| 31 |
21105984 | Plasmodium salvages cholesterol internalized by LDL and synthesized de novo in the liver. | 2011 Apr |
1 |
| 32 |
21903868 | A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro. | 2011 Nov |
3 |
| 33 |
20053345 | 24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury. | 2010 Mar 10 |
1 |
| 34 |
20413873 | Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesis. | 2010 |
2 |
| 35 |
20560544 | Targeting isoprenoid biosynthesis for drug discovery: bench to bedside. | 2010 Sep 21 |
1 |
| 36 |
20645653 | Molecular docking studies to map the binding site of squalene synthase inhibitors on dehydrosqualene synthase of Staphylococcus aureus. | 2010 Oct |
2 |
| 37 |
21122677 | Novel therapies and new targets of treatment for familial hypercholesterolemia. | 2010 Sep-Oct |
1 |
| 38 |
19054015 | Squalene synthase: a critical enzyme in the cholesterol biosynthesis pathway. | 2009 Jan |
8 |
| 39 |
19367148 | Pharmacologic inhibition of squalene synthase and other downstream enzymes of the cholesterol synthesis pathway: a new therapeutic approach to treatment of hypercholesterolemia. | 2009 Mar-Apr |
4 |
| 40 |
19885625 | Changes in the expression of cholesterol metabolism-associated genes in HCV-infected liver: a novel target for therapy? | 2009 Dec |
2 |
| 41 |
18350552 | K45R variant of squalene synthase increases total cholesterol levels in two study samples from a French Canadian population. | 2008 May |
5 |
| 42 |
18593925 | Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma. | 2008 Jul 1 |
2 |
| 43 |
18676367 | Regulation of cholesterologenesis by the oxysterol receptor, LXRalpha. | 2008 Sep 26 |
2 |
| 44 |
17209661 | Squalene synthase inhibitors : clinical pharmacology and cholesterol-lowering potential. | 2007 |
4 |
| 45 |
17483544 | Squalene synthase, a determinant of Raft-associated cholesterol and modulator of cancer cell proliferation. | 2007 Jun 29 |
4 |
| 46 |
17583757 | Squalestatin protects neurons and reduces the activation of cytoplasmic phospholipase A2 by Abeta(1-42). | 2007 Aug |
1 |
| 47 |
17993811 | New targets and emerging therapies for reducing LDL cholesterol. | 2007 Dec |
1 |
| 48 |
15857307 | New lipid-lowering agents acting on LDL receptors. | 2005 |
1 |
| 49 |
16198340 | Antiproliferative and ultrastructural effects of BPQ-OH, a specific inhibitor of squalene synthase, on Leishmania amazonensis. | 2005 Dec |
1 |
| 50 |
15215084 | In vitro and in vivo activities of E5700 and ER-119884, two novel orally active squalene synthase inhibitors, against Trypanosoma cruzi. | 2004 Jul |
1 |