Title : The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis.

Pub. Date : 2019 Jan 16

PMID : 30578317






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Insertion of the weakly hydrophobic tail-anchor (TA) of SQS into the ER membrane by the EMC ensures sufficient flux through the sterol biosynthetic pathway while biogenesis of polytopic SOAT1 promoted by the EMC provides cells with the ability to store free cholesterol as inert cholesteryl esters. Cholesterol farnesyl-diphosphate farnesyltransferase 1 Homo sapiens