Title : Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma.

Pub. Date : 2008 Jul 1

PMID : 18593925






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 HCC sensitivity to chemotherapy acting via mitochondria is enhanced upon cholesterol depletion by inhibition of hydroxymethylglutaryl-CoA reductase or squalene synthase (SS), which catalyzes the first committed step in cholesterol biosynthesis. Cholesterol farnesyl-diphosphate farnesyltransferase 1 Homo sapiens
2 HCC sensitivity to chemotherapy acting via mitochondria is enhanced upon cholesterol depletion by inhibition of hydroxymethylglutaryl-CoA reductase or squalene synthase (SS), which catalyzes the first committed step in cholesterol biosynthesis. Cholesterol farnesyl-diphosphate farnesyltransferase 1 Homo sapiens