gemcitabine

tumor protein p53 ; Homo sapiens







77 Article(s)
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51 20976259 Modulation of the ribonucleotide reductase-antimetabolite drug interaction in cancer cell lines. 2010 Sep 28 2
52 19887545 Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents. 2009 Nov 1
53 18690840 FHIT and p53 status and response to platinum-based treatment in advanced non-small cell lung cancer. 2008 Aug 1
54 21479491 Role of ASC in hypoxia-mediated cell death in pancreatic cancer. 2008 Nov-Dec 1
55 17671697 Regulation of DR-5 protein and mitochondrial transmembrane potential by gemcitabine, a possible mechanism of gemcitabine-enhanced TRAIL-induced apoptosis. 2007 Sep 2
56 16505115 c-Abl-independent p73 stabilization during gemcitabine- or 4'-thio-beta-D-arabinofuranosylcytosine-induced apoptosis in wild-type and p53-null colorectal cancer cells. 2006 Feb 11
57 16690105 Determination of the mechanism of gemcitabine modulation of cisplatin drug resistance in panel of human endometrial cancer cell lines. 2006 Nov 1
58 16820892 Growth inhibition and apoptosis induction in ovarian cancer cells. 2006 Aug 1
59 17079445 Nongenotoxic p53 activation protects cells against S-phase-specific chemotherapy. 2006 Nov 1 2
60 16006755 Enhancement of gemcitabine-induced apoptosis by restoration of p53 function in human pancreatic tumors. 2005 3
61 16238441 Unraveling the mechanism of radiosensitization by gemcitabine: the role of TP53. 2005 Nov 1
62 15199526 Promising combination therapies with gemcitabine. 2004 Apr 2
63 15464472 Proteasome inhibition sensitizes non-small-cell lung cancer to gemcitabine-induced apoptosis. 2004 Oct 1
64 15476743 Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. 2004 Oct 19 2
65 12597983 Preclinical evaluation of a radiosensitizing effect of gemcitabine in p53 mutant and p53 wild type bladder cancer cells. 2003 Feb 1
66 12684687 The effect of loss of Brca1 on the sensitivity to anticancer agents in p53-deficient cells. 2003 May 1
67 12811511 Sensitization of human breast cancer cells to gemcitabine by the protein kinase C modulator bryostatin 1. 2003 Sep 1
68 11802204 Expression of a non-functional p53 affects the sensitivity of cancer cells to gemcitabine. 2002 Feb 1 6
69 11458051 Functional p53 mutation as a molecular determinant of paclitaxel and gemcitabine susceptibility in human bladder cancer. 2001 Aug 2
70 11489842 Radiosensitization by gemcitabine in p53 wild-type and mutant MCF-7 breast carcinoma cell lines. 2001 Aug 2
71 11585734 Therapeutic efficacy of E2F1 in pancreatic cancer correlates with TP73 induction. 2001 Oct 1 1
72 11751391 Interaction of p53 and DNA-PK in response to nucleoside analogues: potential role as a sensor complex for DNA damage. 2001 Dec 15 6
73 10803919 The role of p53 in gemcitabine-mediated cytotoxicity and radiosensitization. 2000 6
74 10811472 Modulation of drug cytotoxicity by reintroduction of wild-type p53 gene (Ad5CMV-p53) in human pancreatic cancer. 2000 Apr 1
75 11085531 The role of cell cycle progression in radiosensitization by 2',2'-difluoro-2'-deoxycytidine. 2000 Nov 1 2
76 10341297 Induction of growth inhibition and apoptosis in pancreatic cancer cells by auristatin-PE and gemcitabine. 1999 Jun 1
77 9772293 Cell cycle arrest in ovarian cancer cell lines does not depend on p53 status upon treatment with cytostatic drugs. 1998 Nov 1