Title : The role of cell cycle progression in radiosensitization by 2',2'-difluoro-2'-deoxycytidine.

Pub. Date : 2000 Nov 1

PMID : 11085531






2 Functional Relationships(s)
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1 After a 24 h incubation with dFdCyd alone or in combination with ionizing radiation, U251 cells readily accumulated in S-phase, which remained elevated for at least 72 h, consistent with previous results in other mutant p53 cell lines. gemcitabine tumor protein p53 Homo sapiens
2 These results suggest that the G1 block in D54 cells resulting from wild-type p53 induction prevented radiosensitization by dFdCyd. gemcitabine tumor protein p53 Homo sapiens