Title : The effect of loss of Brca1 on the sensitivity to anticancer agents in p53-deficient cells.

Pub. Date : 2003 May

PMID : 12684687






1 Functional Relationships(s)
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1 We report that Brca1-deficiency in p53-null cells was associated with increased sensitivity to the topoisomerase I poisons camptothecin and topotecan, the topoisomerase II poisons doxorubicin, mitoxantrone and etoposide, and to the platinum compounds carboplatin and oxaliplatin, but not to the antimetabolites 5-fluorouracil and gemcitabine and the taxanes docetaxel and paclitaxel. gemcitabine tumor protein p53 Homo sapiens