Pub. Date : 2002 Feb 1
PMID : 11802204
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Expression of a non-functional p53 affects the sensitivity of cancer cells to gemcitabine. | gemcitabine | tumor protein p53 | Homo sapiens |
| 2 | The present study was performed to gain insight into the role of p53 status on the cytotoxicity of gemcitabine on cancer cells. | gemcitabine | tumor protein p53 | Homo sapiens |
| 3 | This corresponded with suppression of Bcl-2 and Bcl-X/L expression in wt-p53 cells exposed to gemcitabine whereas Bcl-2 levels remained stable and Bcl-X/L levels increased in mut-p53 cells exposed to gemcitabine. | gemcitabine | tumor protein p53 | Homo sapiens |
| 4 | We conclude that the p53 status of cancer cells influences their sensitivity to gemcitabine cytotoxicity. | gemcitabine | tumor protein p53 | Homo sapiens |
| 5 | Our evidence suggests that loss of p53 function leads to loss of cell cycle control and alterations in the apoptotic cascade, conferring resistance to gemcitabine in cancer cell lines displaying a mut-p53. | gemcitabine | tumor protein p53 | Homo sapiens |
| 6 | Our evidence suggests that loss of p53 function leads to loss of cell cycle control and alterations in the apoptotic cascade, conferring resistance to gemcitabine in cancer cell lines displaying a mut-p53. | gemcitabine | tumor protein p53 | Homo sapiens |