Pub. Date : 2001 Dec 15
PMID : 11751391
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we report that the DNA-dependent protein kinase (DNA-PK) and p53 are able to form a protein complex that interacts with the gemcitabine-containing DNA and plays a role in signaling to apoptotic pathways. | gemcitabine | tumor protein p53 | Homo sapiens |
| 2 | DNA-PK/Ku and p53 were copurified in a protein fraction that binds to gemcitabine-containing DNA in preference to normal DNA. | gemcitabine | tumor protein p53 | Homo sapiens |
| 3 | Treatment with gemcitabine resulted in an increase of DNA-PK and p53 protein and an increase in the phosphorylation of p53 at Ser15. | gemcitabine | tumor protein p53 | Homo sapiens |
| 4 | Treatment with gemcitabine resulted in an increase of DNA-PK and p53 protein and an increase in the phosphorylation of p53 at Ser15. | gemcitabine | tumor protein p53 | Homo sapiens |
| 5 | Furthermore, confocal microscopy demonstrated a colocalization of DNA-PK and p53 to the nucleus in cells treated with gemcitabine. | gemcitabine | tumor protein p53 | Homo sapiens |
| 6 | Although the wild-type p53 present in the protein complex exhibited 3"-5" exonuclease activity, it was incapable of excising the incorporated gemcitabine from DNA. | gemcitabine | tumor protein p53 | Homo sapiens |