Pub. Date : 2000
PMID : 10803919
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The role of p53 in gemcitabine-mediated cytotoxicity and radiosensitization. | gemcitabine | tumor protein p53 | Homo sapiens |
| 2 | PURPOSE: We compared the cytotoxic and radiosensitizing effects of gemcitabine (2",2"-difluoro-2"-deoxycytidine, dFdCyd), a clinically valuable radiosensitizer, in colon cancer RKO cells which differed in their p53 status. | gemcitabine | tumor protein p53 | Homo sapiens |
| 3 | The cytotoxic effect of dFdCyd in RKO-P cells was accompanied by induction of the proapoptotic protein Bax at the time when p53 was induced. | gemcitabine | tumor protein p53 | Homo sapiens |
| 4 | In contrast, similar treatment of RKO-E6 cells with dFdCyd resulted in only limited expression of Bax, suggesting that the cytotoxic effect of dFdCyd was mediated, in part, by a p53-dependent apoptosis pathway. | gemcitabine | tumor protein p53 | Homo sapiens |
| 5 | In contrast, similar treatment of RKO-E6 cells with dFdCyd resulted in only limited expression of Bax, suggesting that the cytotoxic effect of dFdCyd was mediated, in part, by a p53-dependent apoptosis pathway. | gemcitabine | tumor protein p53 | Homo sapiens |
| 6 | CONCLUSION: These results suggest that p53 status may influence dFdCyd-mediated apoptosis, cytotoxicity, and cell cycle progression but do not support an important role for p53 in radiosensitization. | gemcitabine | tumor protein p53 | Homo sapiens |