Title : Modulation of the ribonucleotide reductase-antimetabolite drug interaction in cancer cell lines.

Pub. Date : 2010 Sep 28

PMID : 20976259






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Cell lines with truncation, deletion, and null status of p53 were resistant to gemcitabine without apparent relationship to RRM1 levels. gemcitabine tumor protein p53 Homo sapiens
2 The impact of p53 mutations in patients treated with gemcitabine should be studied in prospective clinical trials to develop a model with improved precision of predicting drug efficacy. gemcitabine tumor protein p53 Homo sapiens