Pub. Date : 2006 Feb
PMID : 16505115
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nucleoside anticancer drugs like gemcitabine (2"-deoxy-2",2"-difluorocytidine) are potent inducers of p53, and ectopic expression of wild-type p53 sensitizes cells to these agents. | gemcitabine | tumor protein p53 | Homo sapiens |
| 2 | Nucleoside anticancer drugs like gemcitabine (2"-deoxy-2",2"-difluorocytidine) are potent inducers of p53, and ectopic expression of wild-type p53 sensitizes cells to these agents. | gemcitabine | tumor protein p53 | Homo sapiens |
| 3 | Nucleoside anticancer drugs like gemcitabine (2"-deoxy-2",2"-difluorocytidine) are potent inducers of p53, and ectopic expression of wild-type p53 sensitizes cells to these agents. | gemcitabine | tumor protein p53 | Homo sapiens |
| 4 | Nucleoside anticancer drugs like gemcitabine (2"-deoxy-2",2"-difluorocytidine) are potent inducers of p53, and ectopic expression of wild-type p53 sensitizes cells to these agents. | gemcitabine | tumor protein p53 | Homo sapiens |
| 5 | T-ara-C and gemcitabine markedly induced p53 accumulation as well as increased levels of phospho-p53 (Ser15/Ser20/Ser46) and induced its binding to a consensus p53 response element. | gemcitabine | tumor protein p53 | Homo sapiens |
| 6 | T-ara-C and gemcitabine markedly induced p53 accumulation as well as increased levels of phospho-p53 (Ser15/Ser20/Ser46) and induced its binding to a consensus p53 response element. | gemcitabine | tumor protein p53 | Homo sapiens |
| 7 | T-ara-C and gemcitabine markedly induced p53 accumulation as well as increased levels of phospho-p53 (Ser15/Ser20/Ser46) and induced its binding to a consensus p53 response element. | gemcitabine | tumor protein p53 | Homo sapiens |
| 8 | Despite robust activation of p53 by T-ara-C and gemcitabine, we found that wild-type and p53-/- HCT 116 cells exhibited almost equivalent sensitivity towards these nucleosides. | gemcitabine | tumor protein p53 | Homo sapiens |
| 9 | Examination of p73 revealed that T-ara-C and gemcitabine markedly increased p73 protein levels and p73 DNA-binding activities in both p53-/- and wild-type cells. | gemcitabine | tumor protein p53 | Homo sapiens |
| 10 | HCT 116 lines, wherein the downstream p53/p73 targets Bax and PUMA (p53 up-regulated modulator of apoptosis) were deleted, were less sensitive to T-ara-C and gemcitabine. | gemcitabine | tumor protein p53 | Homo sapiens |
| 11 | HCT 116 lines, wherein the downstream p53/p73 targets Bax and PUMA (p53 up-regulated modulator of apoptosis) were deleted, were less sensitive to T-ara-C and gemcitabine. | gemcitabine | tumor protein p53 | Homo sapiens |