Bortezomib

nuclear factor kappa B subunit 1 ; Homo sapiens







166 Article(s)
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51 24485799 Romidepsin induces cell cycle arrest, apoptosis, histone hyperacetylation and reduces matrix metalloproteinases 2 and 9 expression in bortezomib sensitized non-small cell lung cancer cells. 2014 Apr 1
52 24899604 Molecular mechanisms of converting K562/DNR cellular drug-resistance by bortezomib. 2014 4
53 24908318 Chromatin immunoprecipitation analysis of bortezomib-mediated inhibition of NFκB recruitment to IL-1β and TNFα gene promoters in human macrophages. 2014 6
54 25089799 Bcl3 regulates pro-survival and pro-inflammatory gene expression in cutaneous T-cell lymphoma. 2014 Nov 1
55 25674239 Morphoproteomics identifies constitutive activation of the mTORC2/Akt and NF-κB pathways and expressions of IGF-1R, Sirt1, COX-2, and FASN in peripheral T-cell lymphomas: pathogenetic implications and therapeutic options. 2014 1
56 22791234 Phase II 2-arm trial of the proteasome inhibitor, PS-341 (bortezomib) in combination with irinotecan or PS-341 alone followed by the addition of irinotecan at time of progression in patients with locally recurrent or metastatic squamous cell carcinoma of the head and neck (E1304): a trial of the Eastern Cooperative Oncology Group. 2013 Jul 1
57 23340716 Bortezomib-enhanced radiosensitization through the suppression of radiation-induced nuclear factor-κB activity in human oral cancer cells. 2013 Mar 5
58 23395385 Impact of global and gene-specific DNA methylation pattern in relapsed multiple myeloma patients treated with bortezomib. 2013 Jun 1
59 23416210 Bortezomib sensitivity of acute myeloid leukemia CD34(+) cells can be enhanced by targeting the persisting activity of NF-κB and the accumulation of MCL-1. 2013 Jun 2
60 23613854 Anti-CD70 immunocytokines for exploitation of interferon-γ-induced RIP1-dependent necrosis in renal cell carcinoma. 2013 1
61 23657944 NF-κB inhibition by bortezomib permits IFN-γ-activated RIP1 kinase-dependent necrosis in renal cell carcinoma. 2013 Aug 3
62 23894194 Proteasome inhibition by bortezomib increases IL-8 expression in androgen-independent prostate cancer cells: the role of IKKα. 2013 Sep 1 3
63 24055520 Induction of steroid sulfatase expression in PC-3 human prostate cancer cells by insulin-like growth factor II. 2013 Nov 25 1
64 24085292 Long-term incubation with proteasome inhibitors (PIs) induces IκBα degradation via the lysosomal pathway in an IκB kinase (IKK)-dependent and IKK-independent manner. 2013 Nov 8 1
65 24156429 [Effect of PCI-32765 and bortezomib on proliferation and apoptosis of B-cell tumor cell lines and its mechanisms]. 2013 Oct 1
66 21792887 Nuclear factor kappa B pathway associated biomarkers in AIDS defining malignancies. 2012 Jun 1 2
67 22286145 Ischemia-reperfusion injury in rat steatotic liver is dependent on NFκB P65 activation. 2012 Jun 1
68 22393418 Blocking autophagy prevents bortezomib-induced NF-κB activation by reducing I-κBα degradation in lymphoma cells. 2012 1
69 22436457 Synthetic lethal screen identifies NF-κB as a target for combination therapy with topotecan for patients with neuroblastoma. 2012 Mar 21 1
70 22512091 The proteasome inhibitor bortezomib reverses P-glycoprotein-mediated leukemia multi-drug resistance through the NF-kappaB pathway. 2012 Feb 4
71 22532603 Proteasome inhibition blocks NF-κB and ERK1/2 pathways, restores antigen expression, and sensitizes resistant human melanoma to TCR-engineered CTLs. 2012 Jun 1
72 22819259 Blockade of NFκB activity by Sunitinib increases cell death in Bortezomib-treated endometrial carcinoma cells. 2012 Oct 2
73 23048077 Mechanisms of activity of the TORC1 inhibitor everolimus in Waldenstrom macroglobulinemia. 2012 Dec 15 2
74 23257433 [Effects of arsenic trioxide combined with bortezomib on proliferation and apoptosis of K562 cells and their mechanism]. 2012 Dec 1
75 20674018 NF-κB localization in multiple myeloma plasma cells and mesenchymal cells. 2011 Jan 2
76 21170083 NF-κB addiction and its role in cancer: 'one size does not fit all'. 2011 Apr 7 2
77 21174067 Combined treatment with bortezomib plus bafilomycin A1 enhances the cytocidal effect and induces endoplasmic reticulum stress in U266 myeloma cells: crosstalk among proteasome, autophagy-lysosome and ER stress. 2011 Mar 1
78 21220502 Bortezomib sensitizes malignant human glioma cells to TRAIL, mediated by inhibition of the NF-{kappa}B signaling pathway. 2011 Jan 4
79 21224428 Bortezomib induces nuclear translocation of IκBα resulting in gene-specific suppression of NF-κB--dependent transcription and induction of apoptosis in CTCL. 2011 Feb 14
80 21246525 A phase 2 trial of bortezomib followed by the addition of doxorubicin at progression in patients with recurrent or metastatic adenoid cystic carcinoma of the head and neck: a trial of the Eastern Cooperative Oncology Group (E1303). 2011 Aug 1 1
81 21441948 Triptolide inhibits the proliferation of cells from lymphocytic leukemic cell lines in association with downregulation of NF-κB activity and miR-16-1*. 2011 Apr 1
82 21487323 Effects and mechanisms of the combination of suberoylanilide hydroxamic acid and bortezomib on the anticancer property of gemcitabine in pancreatic cancer. 2011 Aug 1
83 21768098 Nuclear factor-kappaB (NF-kappaB) mediates a protective response in cancer cells treated with inhibitors of fatty acid synthase. 2011 Sep 9 2
84 21850367 Quinone methide tripterine, celastrol, induces apoptosis in human myeloma cells via NF-κB pathway. 2011 Nov 1
85 23467537 Reversion of Multidrug-Resistance by Proteasome Inhibitor Bortezomib in K562/DNR Cell Line. 2011 Mar 3
86 19835847 Proteasome inhibition up-regulates inflammatory gene transcription induced by an atypical pathway of NF-kappaB activation. 2010 Mar 1 1
87 19850643 Nuclear factor-kappa B pathway and response in a phase II trial of bortezomib and docetaxel in patients with recurrent and/or metastatic head and neck squamous cell carcinoma. 2010 Apr 1
88 20006625 Bortezomib suppresses focal adhesion kinase expression via interrupting nuclear factor-kappa B. 2010 Jan 30 3
89 20515939 The NF-kappaB inhibitor LC-1 has single agent activity in multiple myeloma cells and synergizes with bortezomib. 2010 Jun 1
90 20592098 The clinically approved proteasome inhibitor PS-341 efficiently blocks influenza A virus and vesicular stomatitis virus propagation by establishing an antiviral state. 2010 Sep 2
91 20649468 The treatment of traumatic brain injury with velcade. 2010 Sep 1
92 20651984 Calcium channel blocker verapamil enhances endoplasmic reticulum stress and cell death induced by proteasome inhibition in myeloma cells. 2010 Jul 1
93 20702412 Pro-inflammatory genes as biomarkers and therapeutic targets in oral squamous cell carcinoma. 2010 Oct 15 1
94 20872175 Targeting NF-κB in infantile hemangioma-derived stem cells reduces VEGF-A expression. 2010 Dec 2
95 21269258 Focal adhesion kinase as a therapeutic target of bortezomib. 2010 Dec 5
96 21472287 Synergistic induction of apoptosis in HeLa cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitor SAHA. 2010 Jul-Aug 1
97 18461345 Differential radiation sensitization of human cervical cancer cell lines by the proteasome inhibitor velcade (bortezomib, PS-341). 2009 Jan 2
98 19087975 Proteasome inhibition by bortezomib decreases proliferation and increases apoptosis in ovarian granulosa cell tumors. 2009 Apr 1
99 19327235 The proteasome inhibitor bortezomib inhibits the release of NFkappaB-inducible cytokines and induces apoptosis of activated T cells from rheumatoid arthritis patients. 2009 Jan-Feb 2
100 19380866 Differential efficacy of bortezomib plus chemotherapy within molecular subtypes of diffuse large B-cell lymphoma. 2009 Jun 11 1