Title : The clinically approved proteasome inhibitor PS-341 efficiently blocks influenza A virus and vesicular stomatitis virus propagation by establishing an antiviral state.

Pub. Date : 2010 Sep

PMID : 20592098






2 Functional Relationships(s)
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1 Rather, PS-341 treatment resulted in an induction of IkappaB degradation and activation of NF-kappaB as well as the JNK/AP-1 pathway. Bortezomib nuclear factor kappa B subunit 1 Homo sapiens
2 Thus, we conclude that PS-341 blocks IAV and VSV replication by inducing an antiviral state mediated by the NF-kappaB-dependent expression of antivirus-acting gene products. Bortezomib nuclear factor kappa B subunit 1 Homo sapiens