Title : Synergistic induction of apoptosis in HeLa cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitor SAHA.

Pub. Date : 2010 Jul-Aug

PMID : 21472287






1 Functional Relationships(s)
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1 The combination of bortezomib and SAHA caused an increase in the ratio of bax/bcl-2 expression, inhibited the nuclear transportation of NF-kappaB, and down-regulated Akt expression and phosphorylation in HeLa cells. Bortezomib nuclear factor kappa B subunit 1 Homo sapiens