Title : Anti-CD70 immunocytokines for exploitation of interferon-γ-induced RIP1-dependent necrosis in renal cell carcinoma.

Pub. Date : 2013

PMID : 23613854






1 Functional Relationships(s)
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1 RCC cells display basally-elevated NF-kappaB activity, and inhibiting NF-kappaB in these cells, for example by using the small-molecule proteasome blocker bortezomib, sensitizes them to RIP1-dependent necrotic death following exposure to IFN-gamma. Bortezomib nuclear factor kappa B subunit 1 Homo sapiens