Pub. Date : 2011 Mar
PMID : 23467537
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | After treatment with PS-341, a proteasome inhibitor, the IkappaB degradation was inhibited, IkappaB expression increased, NF-kappaB and P-gp expression decreased in a time dependent manner. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Compared to DNR group, the NF-kappaB p65 activity of DNR+PS-341 group was decreased. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | The mechanism may be that bortezomib decreases the degradation of IkappaB and the expression of NF-kappaB and P-gp, therefore induces the apoptosis of multi-drug resistant cells. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |