Pub. Date : 2013 Mar
PMID : 23340716
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bortezomib is a proteasome inhibitor and a drug used for molecular-targeted therapy (targets NF-kappaB). | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | We demonstrate that bortezomib inhibits NF-kappaB activity and cell proliferation. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | The combined treatment with bortezomib and radiation (RT) suppressed NF-kappaB activity and cell growth in vitro and in vivo compared with RT treatment alone. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | To investigate the mechanisms by which bortezomib suppresses tumor growth, the expression of signaling molecules downstream of NF-kappaB were examined by ELISA. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | A novel molecular targeting therapy including bortezomib may be effective in the treatment of oral cancer by suppressing NF-kappaB activity. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |