| 1 |
33034275 | Mutational landscape of K-Ras substitutions at 12th position-a systematic molecular dynamics approach. | 2022 Mar |
2 |
| 2 |
34787842 | 1 H, 15 N and 13 C resonance assignments of the Q61H mutant of human KRAS bound to GDP. | 2022 Apr |
1 |
| 3 |
34920161 | In silico comparative analysis of KRAS mutations at codons 12 and 13: Structural modifications of P-Loop, switch I&II regions preventing GTP hydrolysis. | 2022 Feb |
5 |
| 4 |
34988297 | Biochemical characterization of the interaction between KRAS and Argonaute 2. | 2022 Mar |
1 |
| 5 |
35053550 | A Breakthrough Brought about by Targeting KRASG12C: Nonconformity Is Punished. | 2022 Jan 13 |
1 |
| 6 |
35075146 | KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge. | 2022 Jan 25 |
2 |
| 7 |
35105836 | Gaussian network model revisited: effects of mutation and ligand binding on protein behavior. | 2022 Mar 7 |
1 |
| 8 |
35142321 | Predicting the conformational variability of oncogenic GTP-bound G12D mutated KRas-4B proteins at zwitterionic model cell membranes. | 2022 Feb 24 |
4 |
| 9 |
35158284 | Discovery of ARS-1620 analogs as KRas G12C inhibitors with high in vivo antitumor activity. | 2022 Apr |
3 |
| 10 |
35202574 | Regulation of GTPase function by autophosphorylation. | 2022 Mar 3 |
1 |
| 11 |
35267628 | Direct Targeting KRAS Mutation in Non-Small Cell Lung Cancer: Focus on Resistance. | 2022 Mar 4 |
2 |
| 12 |
35297922 | Identification of functional substates of KRas during GTP hydrolysis with enhanced sampling simulations. | 2022 Mar 30 |
3 |
| 13 |
35425180 | Q61 mutant-mediated dynamics changes of the GTP-KRAS complex probed by Gaussian accelerated molecular dynamics and free energy landscapes. | 2022 Jan 5 |
3 |
| 14 |
35462078 | Millisecond molecular dynamics simulations of KRas-dimer formation and interfaces. | 2022 Apr 23 |
1 |
| 15 |
35463958 | Autopromotion of K-Ras4B Feedback Activation Through an SOS-Mediated Long-Range Allosteric Effect. | 2022 |
1 |
| 16 |
35586192 | Free Energy Profiles Relating With Conformational Transition of the Switch Domains Induced by G12 Mutations in GTP-Bound KRAS. | 2022 |
3 |
| 17 |
35614853 | Structural and biophysical properties of farnesylated KRas interacting with the chaperone SmgGDS-558. | 2022 May 25 |
2 |
| 18 |
35631410 | Virtual Screening Based on Machine Learning Explores Mangrove Natural Products as KRASG12C Inhibitors. | 2022 May 8 |
1 |
| 19 |
33309163 | Design, synthesis and pharmacological evaluation of bicyclic and tetracyclic pyridopyrimidinone analogues as new KRASG12C inhibitors. | 2021 Mar 5 |
1 |
| 20 |
33680360 | Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling proteins. | 2021 |
2 |
| 21 |
33723061 | Molecular assemblies of the catalytic domain of SOS with KRas and oncogenic mutants. | 2021 Mar 23 |
4 |
| 22 |
33739090 | Mutation-Induced Impacts on the Switch Transformations of the GDP- and GTP-Bound K-Ras: Insights from Multiple Replica Gaussian Accelerated Molecular Dynamics and Free Energy Analysis. | 2021 Apr 26 |
8 |
| 23 |
33744388 | Intracellular KRAS-specific antibody enhances the anti-tumor efficacy of gemcitabine in pancreatic cancer by inducing endosomal escape. | 2021 Jun 1 |
1 |
| 24 |
34237589 | Residue interaction networks of K-Ras protein with water molecules identifies the potential role of switch II and P-loop. | 2021 Aug |
1 |
| 25 |
34345014 | RNF141 interacts with KRAS to promote colorectal cancer progression. | 2021 Sep |
1 |
| 26 |
34347509 | Cytotoxic activity of KRAS inhibitors in combination with chemotherapeutics. | 2021 Sep |
2 |
| 27 |
34551282 | KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis. | 2021 Nov 18 |
1 |
| 28 |
34570515 | Conformational Fluctuations in GTP-Bound K-Ras: A Metadynamics Perspective with Harmonic Linear Discriminant Analysis. | 2021 Oct 25 |
2 |
| 29 |
34625747 | A structural model of a Ras-Raf signalosome. | 2021 Oct |
1 |
| 30 |
34703570 | Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization. | 2021 Oct 6 |
2 |
| 31 |
32227412 | Two Distinct Structures of Membrane-Associated Homodimers of GTP- and GDP-Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement. | 2020 Jun 26 |
2 |
| 32 |
32257057 | The quaternary assembly of KRas4B with Raf-1 at the membrane. | 2020 |
1 |
| 33 |
32486141 | A H-REV107 Peptide Inhibits Tumor Growth and Interacts Directly with Oncogenic KRAS Mutants. | 2020 May 30 |
1 |
| 34 |
32636302 | The molecular basis for immune dysregulation by the hyperactivated E62K mutant of the GTPase RAC2. | 2020 Aug 21 |
1 |
| 35 |
32715349 | Structure-based inhibitor design of mutant RAS proteins-a paradigm shift. | 2020 Dec |
2 |
| 36 |
33145412 | GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf. | 2020 Oct 28 |
4 |
| 37 |
33153459 | Discernment between candidate mechanisms for KRAS G13D colorectal cancer sensitivity to EGFR inhibitors. | 2020 Nov 5 |
4 |
| 38 |
33196710 | [Therapeutic possibilities in KRAS-mutant lung adenocarcinoma]. | 2020 Sep 23 |
2 |
| 39 |
33266473 | Influence of Cholesterol on the Orientation of the Farnesylated GTP-Bound KRas-4B Binding with Anionic Model Membranes. | 2020 Nov 22 |
1 |
| 40 |
30683722 | Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. | 2019 Feb 12 |
2 |
| 41 |
30930748 | Galectin-3 (MAC-2) Controls Microglia Phenotype Whether Amoeboid and Phagocytic or Branched and Non-phagocytic by Regulating the Cytoskeleton. | 2019 |
1 |
| 42 |
31219673 | Optical Control of the GTP Affinity of K-Ras(G12C) by a Photoswitchable Inhibitor. | 2019 Dec 2 |
2 |
| 43 |
31306575 | Intrinsic GTPase Activity of K-RAS Monitored by Native Mass Spectrometry. | 2019 Aug 6 |
1 |
| 44 |
31339036 | PIP2 Influences the Conformational Dynamics of Membrane-Bound KRAS4b. | 2019 Aug 20 |
2 |
| 45 |
31409810 | Oncogenic G12D mutation alters local conformations and dynamics of K-Ras. | 2019 Aug 13 |
2 |
| 46 |
31611389 | KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis. | 2019 Oct 29 |
4 |
| 47 |
31827279 | KRAS4A directly regulates hexokinase 1. | 2019 Dec |
2 |
| 48 |
31853358 | Investigation of GTP-dependent dimerization of G12X K-Ras variants using ultraviolet photodissociation mass spectrometry. | 2019 Sep 14 |
2 |
| 49 |
29229665 | Ras and the Plasma Membrane: A Complicated Relationship. | 2018 Oct 1 |
2 |
| 50 |
29313669 | Design of Small Molecules That Compete with Nucleotide Binding to an Engineered Oncogenic KRAS Allele. | 2018 Feb 27 |
3 |