Pub. Date : 2022 Feb 24
PMID : 35142321
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Predicting the conformational variability of oncogenic GTP-bound G12D mutated KRas-4B proteins at zwitterionic model cell membranes. | Guanosine Triphosphate | KRAS proto-oncogene, GTPase | Homo sapiens |
| 2 | We tested the methodology using a G12D mutated GTP bound oncogenic KRas-4B protein located at the interface of a DOPC/DOPS/cholesterol model anionic cell membrane. | Guanosine Triphosphate | KRAS proto-oncogene, GTPase | Homo sapiens |
| 3 | We have observed that GTP-binding to KRas-4B has huge influence on the stabilisation of the protein and it can potentially help to open Switch I/II druggable pockets, lowering energy barriers between stable states and resulting in cumulative conformers of KRas-4B. | Guanosine Triphosphate | KRAS proto-oncogene, GTPase | Homo sapiens |
| 4 | We have observed that GTP-binding to KRas-4B has huge influence on the stabilisation of the protein and it can potentially help to open Switch I/II druggable pockets, lowering energy barriers between stable states and resulting in cumulative conformers of KRas-4B. | Guanosine Triphosphate | KRAS proto-oncogene, GTPase | Homo sapiens |