Title : Design, synthesis and pharmacological evaluation of bicyclic and tetracyclic pyridopyrimidinone analogues as new KRASG12C inhibitors.

Pub. Date : 2021 Mar 5

PMID : 33309163






1 Functional Relationships(s)
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1 Treatment of 26a with NCI-H358 cells resulted in down-regulation of KRAS-GTP levels and reduction of phosphorylation of downstream ERK and AKT dose-dependently. Guanosine Triphosphate KRAS proto-oncogene, GTPase Homo sapiens