Title : Millisecond molecular dynamics simulations of KRas-dimer formation and interfaces.

Pub. Date : 2022 Apr 23

PMID : 35462078






1 Functional Relationships(s)
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1 Interestingly, we found two Arginine fingers R68 and R149 that directly interact with the beta-phosphate of the GTP bound in KRas, in a manner similar to what is observed in a crystal structure of GAP-HRas complex, which can facilitate the GPT hydrolysis via the Arginine finger of GTPase-activating protein (GAP). Guanosine Triphosphate KRAS proto-oncogene, GTPase Homo sapiens