Title : Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization.

Pub. Date : 2021 Oct 6

PMID : 34703570






2 Functional Relationships(s)
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1 KRAS is a frequently mutated oncogene, and while it is well known that the most prevalent mutation, G12D, impairs GTP hydrolysis, thereby increasing KRAS activation, G12D has also been shown to enhance nanoclustering. Guanosine Triphosphate KRAS proto-oncogene, GTPase Homo sapiens
2 KRAS is a frequently mutated oncogene, and while it is well known that the most prevalent mutation, G12D, impairs GTP hydrolysis, thereby increasing KRAS activation, G12D has also been shown to enhance nanoclustering. Guanosine Triphosphate KRAS proto-oncogene, GTPase Homo sapiens