phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ; Mus musculus






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1 9710440 Lysophosphatidic acid is a major serum noncytokine survival factor for murine macrophages which acts via the phosphatidylinositol 3-kinase signaling pathway. J Clin Invest 1998 Aug 15 4
2 10669416 Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science 2000 Feb 11 1
3 10669417 Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Science 2000 Feb 11 3
4 10847579 Insulin and the beta3-adrenoceptor differentially regulate uncoupling protein-1 expression. Mol Endocrinol 2000 Jun 1
5 11054537 Analysis of the murine phosphoinositide 3-kinase gamma gene. Gene 2000 Oct 3 3
6 11511514 Resistance to thromboembolism in PI3Kgamma-deficient mice. FASEB J 2001 Sep 5
7 11911828 Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function. Immunity 2002 Mar 3
8 12297047 Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell 2002 Sep 20 2
9 12407113 A selective role for phosphatidylinositol 3,4,5-trisphosphate in the Gi-dependent activation of platelet Rap1B. J Biol Chem 2003 Jan 3 2
10 12464394 Involvement of phosphatidylinositol 3-kinase gamma in neutrophil apoptosis. Cell Signal 2003 Feb 1
11 12546701 Phosphoinositide 3-kinase gamma: a key modulator in inflammation and allergy. Biochem Soc Trans 2003 Feb 3
12 12796499 Two waves of platelet secretion induced by thromboxane A2 receptor and a critical role for phosphoinositide 3-kinases. J Biol Chem 2003 Aug 15 1
13 12963636 Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. Circulation 2003 Oct 28 2
14 14980723 Increased level of neuronal phosphoinositide 3-kinase gamma by the activation of mu-opioid receptor in the mouse periaqueductal gray matter: further evidence for the implication in morphine-induced antinociception. Neuroscience 2004 3
15 15231713 Impaired glucose-stimulated insulin secretion, enhanced intraperitoneal insulin tolerance, and increased beta-cell mass in mice lacking the p110gamma isoform of phosphoinositide 3-kinase. Endocrinology 2004 Sep 8
16 15294162 PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects. Cell 2004 Aug 6 3
17 15579443 Ablation of phosphoinositide 3-kinase-gamma reduces the severity of acute pancreatitis. Am J Pathol 2004 Dec 2
18 15705797 The relative role of PLCbeta and PI3Kgamma in platelet activation. Blood 2005 Jul 1 5
19 15797027 p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma. Curr Biol 2005 Mar 29 2
20 15824082 Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma. J Exp Med 2005 Apr 18 1
21 15860757 Cardiac sarcoplasmic reticulum calcium release and load are enhanced by subcellular cAMP elevations in PI3Kgamma-deficient mice. Circ Res 2005 May 27 7
22 16186103 Galpha q inhibits cardiac L-type Ca2+ channels through phosphatidylinositol 3-kinase. J Biol Chem 2005 Dec 2 1
23 16527821 Phosphatidylinositol 3-kinase gamma signaling through protein kinase Czeta induces NADPH oxidase-mediated oxidant generation and NF-kappaB activation in endothelial cells. J Biol Chem 2006 Jun 9 1
24 16543958 Signaling through PI3Kgamma: a common platform for leukocyte, platelet and cardiovascular stress sensing. Thromb Haemost 2006 Jan 4
25 16789742 Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma. J Med Chem 2006 Jun 29 3
26 16856844 Identification of the macromolecular complex responsible for PI3Kgamma-dependent regulation of cAMP levels. Biochem Soc Trans 2006 Aug 4
27 16887102 Effective attenuation of acute lung injury in vivo and the formyl peptide-induced neutrophil activation in vitro by CYL-26z through the phosphoinositide 3-kinase gamma pathway. Biochem Pharmacol 2006 Sep 14 1
28 16980183 Phosphoinositide 3-kinase gamma regulates cardiac contractility by locally controlling cyclic adenosine monophosphate levels. Trends Cardiovasc Med 2006 Oct 6
29 17041586 Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils. Nat Cell Biol 2006 Nov 2
30 17284578 Role of phosphatidylinositol-3 kinase-gamma in the actions of glucagon-like peptide-2 on the murine small intestine. Am J Physiol Endocrinol Metab 2007 Jun 1
31 17322108 Importance of phosphoinositide 3-kinase gamma in the host defense against pneumococcal infection. Am J Respir Crit Care Med 2007 May 1 1
32 17471173 Cryptotanshinone inhibits chemotactic migration in macrophages through negative regulation of the PI3K signaling pathway. Br J Pharmacol 2007 Jul 3
33 17615371 PI3Kgamma is required for PDE4, not PDE3, activity in subcellular microdomains containing the sarcoplasmic reticular calcium ATPase in cardiomyocytes. Circ Res 2007 Aug 17 3
34 17975110 Altered heart rate and sinoatrial node function in mice lacking the cAMP regulator phosphoinositide 3-kinase-gamma. Circ Res 2007 Dec 7 6
35 18025236 Tissue- and stimulus-dependent role of phosphatidylinositol 3-kinase isoforms for neutrophil recruitment induced by chemoattractants in vivo. J Immunol 2007 Dec 1 3
36 18046317 The phosphoinositide-3 kinase gamma-Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity. Kidney Int 2008 Feb 2
37 18268153 Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes. Circulation 2008 Mar 11 1
38 18542100 Role of phosphatidylinositol-3-kinase-gamma (PI3Kgamma)-mediated pathway in 17beta-estradiol-induced killing of L. mexicana in macrophages from C57BL/6 mice. Immunol Cell Biol 2008 Aug-Sep 4
39 18688045 Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning. Circ Res 2008 Sep 12 3
40 19376709 Twice upon a time: PI3K's secret double life exposed. Trends Biochem Sci 2009 May 1
41 19538942 Phosphoinositide 3-kinase gamma inhibitor ameliorates concanavalin A-induced hepatic injury in mice. Biochem Biophys Res Commun 2009 Sep 4 1
42 19828878 Inhibition of phosphoinositide 3-kinase ameliorates dextran sodium sulfate-induced colitis in mice. J Pharmacol Exp Ther 2010 Jan 2
43 19897731 Erythrocyte scaffolding protein p55/MPP1 functions as an essential regulator of neutrophil polarity. Proc Natl Acad Sci U S A 2009 Nov 24 2
44 19907415 Phosphoinositol 3-kinase-gamma mediates antineutrophil cytoplasmic autoantibody-induced glomerulonephritis. Kidney Int 2010 Jan 1
45 19950590 [Intervention effect of PI3Kgamma inhibitor AS605240 on autoimmune myocarditis in mice]. Sichuan Da Xue Xue Bao Yi Xue Ban 2009 Sep 2
46 20004201 Phosphatidylinositol 3-kinase gamma inhibition ameliorates inflammation and tumor growth in a model of colitis-associated cancer. Gastroenterology 2010 Apr 1
47 20007453 Tumor necrosis factor induces matrix metalloproteinases in cardiomyocytes and cardiofibroblasts differentially via superoxide production in a PI3Kgamma-dependent manner. Am J Physiol Cell Physiol 2010 Mar 2
48 20017720 Phosphoinositide 3-kinase gamma (PI3Kgamma) inhibitors for the treatment of inflammation and autoimmune disease. Recent Pat Inflamm Allergy Drug Discov 2010 Jan 2
49 20025958 Involvement of phosphoinositide 3-kinase gamma in the neuro-inflammatory response and cognitive impairments induced by beta-amyloid 1-40 peptide in mice. Brain Behav Immun 2010 Mar 5
50 20028656 The alarmin cytokine, high mobility group box 1, is produced by viable cardiomyocytes and mediates the lipopolysaccharide-induced myocardial dysfunction via a TLR4/phosphatidylinositol 3-kinase gamma pathway. J Immunol 2010 Feb 1 2