Pub. Date : 2010 Mar
PMID : 20025958
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this report we have investigated whether phosphoinositide 3-kinase gamma (PI3Kgamma), which is important in inflammatory cell migration, plays a critical role in the neuro-inflammation, synaptic dysfunction, and cognitive deficits induced by intracerebroventricular injection of Abeta(1-40) in mice. | UNII-042A8N37WH | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | Mus musculus |
| 2 | In this report we have investigated whether phosphoinositide 3-kinase gamma (PI3Kgamma), which is important in inflammatory cell migration, plays a critical role in the neuro-inflammation, synaptic dysfunction, and cognitive deficits induced by intracerebroventricular injection of Abeta(1-40) in mice. | UNII-042A8N37WH | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | Mus musculus |
| 3 | We found that the selective inhibitor of PI3Kgamma, AS605240, was able to attenuate the Abeta(1-40)-induced accumulation of activated astrocytes and microglia in the hippocampus, and decrease immuno-staining for p-Akt and cyclooxygenase-2 (COX-2). | 5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | Mus musculus |
| 4 | Interestingly, Abeta(1-40) activated macrophages treated with AS605240 or another PI3Kgamma inhibitor, AS252424, displayed impaired chemotaxis in vitro, but their expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was unaffected. | 5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | Mus musculus |
| 5 | Interestingly, Abeta(1-40) activated macrophages treated with AS605240 or another PI3Kgamma inhibitor, AS252424, displayed impaired chemotaxis in vitro, but their expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was unaffected. | 5-(5-(4-fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | Mus musculus |