Title : Increased level of neuronal phosphoinositide 3-kinase gamma by the activation of mu-opioid receptor in the mouse periaqueductal gray matter: further evidence for the implication in morphine-induced antinociception.

Pub. Date : 2004

PMID : 14980723






3 Functional Relationships(s)
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1 The aim of the present study was to investigate whether in vivo treatment with morphine, a mu-opioid receptor (MOR) agonist, could directly regulate PI3Kgamma isoform in the mouse periaqueductal gray matter (PAG). Morphine phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Mus musculus
2 A single s.c. injection of morphine caused a marked increase in the number of PI3Kgamma-IR expressing cells in the PAG. Morphine phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Mus musculus
3 These findings suggested that acute treatment with morphine may directly activate the PI3Kgamma/PLCgamma1 pathway in the PAG. Morphine phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Mus musculus