Pub. Date : 2005 May 27
PMID : 15860757
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cardiac sarcoplasmic reticulum calcium release and load are enhanced by subcellular cAMP elevations in PI3Kgamma-deficient mice. | Calcium | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | Mus musculus |
| 2 | Cardiac sarcoplasmic reticulum calcium release and load are enhanced by subcellular cAMP elevations in PI3Kgamma-deficient mice. | Cyclic AMP | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | Mus musculus |
| 3 | The cAMP inhibitor Rp-cAMP eliminated enhanced ECC and SR Ca2+ load in PI3Kgamma-/- without effects in control myocytes. | Cyclic AMP | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | Mus musculus |
| 4 | The cAMP inhibitor Rp-cAMP eliminated enhanced ECC and SR Ca2+ load in PI3Kgamma-/- without effects in control myocytes. | Cyclic AMP | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | Mus musculus |
| 5 | On the other hand, the beta-adrenergic receptor agonist isoproterenol increased I(Ca,L) and Ca2+ transient equally by approximately 2-fold in both PI3Kgamma-/- and PI3Kgamma+/- cardiomyocytes. | Isoproterenol | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | Mus musculus |
| 6 | On the other hand, the beta-adrenergic receptor agonist isoproterenol increased I(Ca,L) and Ca2+ transient equally by approximately 2-fold in both PI3Kgamma-/- and PI3Kgamma+/- cardiomyocytes. | Isoproterenol | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | Mus musculus |
| 7 | Our results establish that PI3Kgamma reduces cardiac contractility in a highly compartmentalized manner by inhibiting cAMP-mediated SR Ca2+ loading without directly affecting other major modulators of ECC, such as AP and I(Ca,L). | Cyclic AMP | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | Mus musculus |