Pub. Date : 2010 Mar
PMID : 20007453
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tumor necrosis factor induces matrix metalloproteinases in cardiomyocytes and cardiofibroblasts differentially via superoxide production in a PI3Kgamma-dependent manner. | Superoxides | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | Mus musculus |
| 2 | We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF-mediated events since TNF-induced superoxide production, MMP expression, and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma. | Superoxides | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | Mus musculus |