Pub. Date : 2001 Sep
PMID : 11511514
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | When platelets from mice lacking the G protein-activated PI3Kgamma isoform were stimulated with ADP, aggregation was impaired. | Adenosine Diphosphate | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | Mus musculus |
| 2 | ADP stimulation of PI3Kgamma-deficient platelets resulted in decreased PKB/Akt phosphorylation and alpha(IIb)beta(3) fibrinogen receptor activation. | Adenosine Diphosphate | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | Mus musculus |
| 3 | These effects did not influence bleeding time but protected PI3Kgamma-null mice from death caused by ADP-induced platelet-dependent thromboembolic vascular occlusion. | Adenosine Diphosphate | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | Mus musculus |
| 4 | This result demonstrates an unsuspected, well-defined role for PI3Kgamma downstream of ADP and suggests that pharmacological targeting of PI3Kgamma has a potential use as antithrombotic therapy. | Adenosine Diphosphate | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | Mus musculus |
| 5 | This result demonstrates an unsuspected, well-defined role for PI3Kgamma downstream of ADP and suggests that pharmacological targeting of PI3Kgamma has a potential use as antithrombotic therapy. | Adenosine Diphosphate | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | Mus musculus |