Title : Phosphatidylinositol 3-kinase gamma signaling through protein kinase Czeta induces NADPH oxidase-mediated oxidant generation and NF-kappaB activation in endothelial cells.

Pub. Date : 2006 Jun 9

PMID : 16527821






1 Functional Relationships(s)
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1 Tumor necrosis factor (TNF) alpha challenge of wild type ECs caused p110gamma translocation to the plasma membrane and phosphatidylinositol 1,4,5-trisphosphate production coupled to ROS production; however, this response was blocked in p110gamma-/- ECs. phosphatidylinositol 1,4,5-trisphosphate phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Mus musculus