| 1 | 9855641 | Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element. | Mol Pharmacol | 1998 Dec |
5 |
| 2 | 10415106 | Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation. | Arch Biochem Biophys | 1999 Aug 1 |
2 |
| 3 | 10628745 | The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. | Mol Endocrinol | 2000 Jan |
5 |
| 4 | 10681370 | The glucocorticoid receptor is essential for induction of cytochrome P-4502B by steroids but not for drug or steroid induction of CYP3A or P-450 reductase in mouse liver. | Drug Metab Dispos | 2000 Mar |
1 |
| 5 | 10748001 | Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. | J Biol Chem | 2000 May 19 |
1 |
| 6 | 10772631 | Rabbit pregnane X receptor is activated by rifampicin. | Drug Metab Dispos | 2000 May |
1 |
| 7 | 10935643 | Humanized xenobiotic response in mice expressing nuclear receptor SXR. | Nature | 2000 Jul 27 |
2 |
| 8 | 11114890 | Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. | Genes Dev | 2000 Dec 1 |
1 |
| 9 | 11165039 | The expression of pregnane X receptor and its target gene, cytochrome P450 3A1, in perinatal mouse. | Mol Cell Endocrinol | 2001 Feb 14 |
9 |
| 10 | 11509573 | Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450. | J Biol Chem | 2001 Oct 19 |
2 |
| 11 | 11581012 | Bisphenol-A, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenobiotic receptor-mediated transcription. | Eur J Endocrinol | 2001 Oct |
6 |
| 12 | 11602523 | Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor. | Drug Metab Dispos | 2001 Nov |
2 |
| 13 | 11751591 | Ligands have various potential effects on the degradation of pregnane X receptor by proteasome. | Endocrinology | 2002 Jan |
12 |
| 14 | 11950789 | Induction of CYP3A expression by dehydroepiandrosterone: involvement of the pregnane X receptor. | Drug Metab Dispos | 2002 May |
6 |
| 15 | 12049174 | Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response. | Pharmacogenomics J | 2002 |
4 |
| 16 | 12509506 | Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor. | Proc Natl Acad Sci U S A | 2003 Jan 7 |
3 |
| 17 | 12569201 | Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance. | Proc Natl Acad Sci U S A | 2003 Feb 4 |
5 |
| 18 | 12587118 | Altered expression and function of P-glycoprotein in dextran sodium sulfate-induced colitis in mice. | J Pharm Sci | 2003 Mar |
1 |
| 19 | 12606758 | Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR. | Mol Pharmacol | 2003 Mar |
6 |
| 20 | 12632254 | Expression of cytochromes P450 3A in mouse lung: effects of dexamethasone and pregnenolone 16alpha-carbonitrile. | Arch Toxicol | 2003 Mar |
4 |
| 21 | 12695338 | Regulation of drug transporter gene expression by nuclear receptors. | Drug Metab Dispos | 2003 May |
7 |
| 22 | 12695359 | Induction of cytochrome P450 3A by paclitaxel in mice: pivotal role of the nuclear xenobiotic receptor, pregnane X receptor. | Drug Metab Dispos | 2003 May |
7 |
| 23 | 12781341 | In vivo activation of the human CYP3A4 promoter in mouse liver and regulation by pregnane X receptors. | Biochem Pharmacol | 2003 Jun 1 |
4 |
| 24 | 12814968 | Nuclear receptor, pregname X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile. | Drug Metab Dispos | 2003 Jul |
6 |
| 25 | 12920130 | Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR. | J Biol Chem | 2003 Nov 7 |
7 |
| 26 | 12923173 | Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity. | J Biol Chem | 2003 Nov 14 |
6 |
| 27 | 12958193 | Genomic characterization and regulation of CYP3a13: role of xenobiotics and nuclear receptors. | FASEB J | 2003 Sep |
1 |
| 28 | 14570758 | Induction of ABCC3 (MRP3) by pregnane X receptor activators. | Drug Metab Dispos | 2003 Nov |
2 |
| 29 | 14667932 | Effects of triaryl phosphates on mouse and human nuclear receptors. | Biochem Pharmacol | 2004 Jan 1 |
1 |
| 30 | 14770174 | CAR/PXR provide directives for Cyp3a41 gene regulation differently from Cyp3a11. | Pharmacogenomics J | 2004 |
2 |
| 31 | 15102959 | Induction of CYP3A by 2,3-oxidosqualene:lanosterol cyclase inhibitors is mediated by an endogenous squalene metabolite in primary cultured rat hepatocytes. | Mol Pharmacol | 2004 May |
4 |
| 32 | 15125996 | A human and mouse pregnane X receptor reporter gene assay in combination with cytotoxicity measurements as a tool to evaluate species-specific CYP3A induction. | Toxicology | 2004 Jun 1 |
1 |
| 33 | 15183191 | Kupffer cells and reactive oxygen species partially mediate lipopolysaccharide-induced downregulation of nuclear receptor pregnane x receptor and its target gene CYP3a in mouse liver. | Free Radic Biol Med | 2004 Jul 1 |
9 |
| 34 | 15219769 | Alterations in the distribution and orexigenic effects of dexamethasone in CAR-null mice. | Pharmacol Biochem Behav | 2004 Jun |
2 |
| 35 | 15340055 | Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes. | Mol Cell Biol | 2004 Sep |
3 |
| 36 | 15347657 | Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver. | J Biol Chem | 2004 Nov 19 |
8 |
| 37 | 15358766 | The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity. | J Biol Chem | 2004 Nov 19 |
5 |
| 38 | 15364542 | Environmental phthalate monoesters activate pregnane X receptor-mediated transcription. | Toxicol Appl Pharmacol | 2004 Sep 15 |
1 |
| 39 | 15454728 | Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene. | Pharmacogenetics | 2004 Oct |
5 |
| 40 | 15456840 | The involvement of the pregnane X receptor in hepatic gene regulation during inflammation in mice. | J Pharmacol Exp Ther | 2005 Feb |
1 |
| 41 | 15456926 | Enhanced acetaminophen toxicity by activation of the pregnane X receptor. | Toxicol Sci | 2004 Dec |
13 |
| 42 | 15595924 | Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms. | Biochem J | 2005 May 1 |
6 |
| 43 | 15611112 | Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion. | J Biol Chem | 2005 Mar 11 |
3 |
| 44 | 15617534 | Melatonin attenuates lipopolysaccharide-induced down-regulation of pregnane X receptor and its target gene CYP3A in mouse liver. | J Pineal Res | 2005 Jan |
5 |
| 45 | 15619241 | Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice. | Hepatology | 2005 Jan |
4 |
| 46 | 15671183 | Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites. | Proc Natl Acad Sci U S A | 2005 Feb 8 |
3 |
| 47 | 15684063 | Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury. | Proc Natl Acad Sci U S A | 2005 Feb 8 |
6 |
| 48 | 15726644 | Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice. | Hepatology | 2005 Mar |
10 |
| 49 | 15846226 | Metabolites of progesterone and the pregnane X receptor: a novel pathway regulating uterine contractility in pregnancy? | Am J Obstet Gynecol | 2005 Apr |
7 |
| 50 | 15869837 | Lipopolysaccharide treatment downregulates the expression of the pregnane X receptor, cyp3a11 and mdr1a genes in mouse placenta. | Toxicology | 2005 Aug 1 |
6 |