Pub. Date : 2005 Apr
PMID : 15846226
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: The purpose of this study was to determine the role of 5beta-dihydroprogesterone (5beta-DHP), acting through the nuclear receptor pregnane X receptor (PXR), in regulating uterine contractility. | 5-alpha-Dihydroprogesterone | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 2 | OBJECTIVE: The purpose of this study was to determine the role of 5beta-dihydroprogesterone (5beta-DHP), acting through the nuclear receptor pregnane X receptor (PXR), in regulating uterine contractility. | 5-alpha-Dihydroprogesterone | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 3 | OBJECTIVE: The purpose of this study was to determine the role of 5beta-dihydroprogesterone (5beta-DHP), acting through the nuclear receptor pregnane X receptor (PXR), in regulating uterine contractility. | 5-alpha-Dihydroprogesterone | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 4 | OBJECTIVE: The purpose of this study was to determine the role of 5beta-dihydroprogesterone (5beta-DHP), acting through the nuclear receptor pregnane X receptor (PXR), in regulating uterine contractility. | 5-alpha-Dihydroprogesterone | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 5 | Chronic in vivo administration of 5beta-DHP to mice with intact PXR, but not in mice with disrupted PXR, causes an increased effect of 1400W, a specific inhibitor of inducible nitric oxide synthase (iNOS). | 5-alpha-Dihydroprogesterone | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 6 | Chronic in vivo administration of 5beta-DHP to mice with intact PXR, but not in mice with disrupted PXR, causes an increased effect of 1400W, a specific inhibitor of inducible nitric oxide synthase (iNOS). | N-((3-(aminomethyl)phenyl)methyl)ethanimidamide | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 7 | CONCLUSION: These data support the hypothesis that metabolites of progesterone may act chronically through a PXR-mediated mechanism to regulate uterine contractility. | Progesterone | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |