Title : Lipopolysaccharide treatment downregulates the expression of the pregnane X receptor, cyp3a11 and mdr1a genes in mouse placenta.

Pub. Date : 2005 Aug 1

PMID : 15869837






6 Functional Relationships(s)
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1 LPS-induced downregulation of PXR, cyp3a11 and mdr1a mRNA in placenta was significantly attenuated after pregnant mice were pre- and post-treated with alpha-phenyl-N-t-butylnitrone (PBN), a free radical spin trapping agent. phenyl-N-tert-butylnitrone nuclear receptor subfamily 1, group I, member 2 Mus musculus
2 LPS-induced downregulation of PXR, cyp3a11 and mdr1a mRNA in placenta was significantly attenuated after pregnant mice were pre- and post-treated with alpha-phenyl-N-t-butylnitrone (PBN), a free radical spin trapping agent. pbn nuclear receptor subfamily 1, group I, member 2 Mus musculus
3 Furthermore, LPS-induced downregulation of PXR, cyp3a11 and mdr1a mRNA in mouse placenta was prevented by N-acetylcysteine (NAC). Acetylcysteine nuclear receptor subfamily 1, group I, member 2 Mus musculus
4 Furthermore, LPS-induced downregulation of PXR, cyp3a11 and mdr1a mRNA in mouse placenta was prevented by N-acetylcysteine (NAC). Acetylcysteine nuclear receptor subfamily 1, group I, member 2 Mus musculus
5 Reactive oxygen species (ROS) may be involved in LPS-induced downregulation of PXR, cyp3a11 and mdr1a in mouse placenta. Reactive Oxygen Species nuclear receptor subfamily 1, group I, member 2 Mus musculus
6 Reactive oxygen species (ROS) may be involved in LPS-induced downregulation of PXR, cyp3a11 and mdr1a in mouse placenta. Reactive Oxygen Species nuclear receptor subfamily 1, group I, member 2 Mus musculus